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Optimized reaction conditions were established, affording the desired compounds in moderate to good yields. The synthesized derivatives were evaluated for cytotoxic activity against a panel of cancer cell lines (M\u2010HeLa, MCF\u20107, HuTu 80, A549), and nonmalignant cells (WI\u201038 and Chang Liver). The highest efficacy was observed against the M\u2010HeLa cell line, with IC50 values ranging from 1.4 to 3.9\u2009\u03bcM, which is 9\u201325 times more potent than the activity of sorafenib, a reference drug. Lead compounds\n                    <jats:bold>3g<\/jats:bold>\n                    and\n                    <jats:bold>3d<\/jats:bold>\n                    demonstrated selectivity toward M\u2010HeLa cells compared to Chang liver cells, suggesting their potential therapeutic value. Mechanistic investigations revealed that\n                    <jats:bold>3g<\/jats:bold>\n                    and\n                    <jats:bold>3d<\/jats:bold>\n                    induce dose\u2010dependent apoptosis via the mitochondrial pathway. Key findings indicate G2\/M phase cell cycle arrest independent of the p53 pathway. Furthermore, a significant decrease in tubulin polymerization\u2010promoting protein (TPPP) levels was observed, indicating tubulin depolymerization and antimitotic activity. Additionally, compound 3d exhibited inhibitory activity against cyclin\u2010dependent kinase 2 (CDK2). These results position bis(diphenylphosphine oxide) derivatives as a promising scaffold for the development of novel anticancer agents.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70285","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T04:59:32Z","timestamp":1777179572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antiproliferative Activity and Acute Toxicity of \u03b1,\u03b2\u2010Bis(diphenylphosphine Oxide)ethanes Obtained by Bisphosphorylation of Acetylenes: Electrosynthesis Under Mild Conditions Versus Improved Superbasic Medium Synthesis"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-7496","authenticated-orcid":false,"given":"Maxim V.","family":"Tarasov","sequence":"first","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry FRC Kazan Scientific Center Russian Academy of Sciences  Kazan Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana V.","family":"Gryaznova","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry FRC Kazan Scientific Center Russian Academy of Sciences  Kazan Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Ivshin","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry FRC Kazan Scientific Center Russian Academy of Sciences  Kazan Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey A.","family":"Katsyuba","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry FRC Kazan Scientific Center Russian Academy of Sciences  Kazan Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana. 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