{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T05:07:03Z","timestamp":1779772023832,"version":"3.53.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["CRG\/2023\/006633"],"award-info":[{"award-number":["CRG\/2023\/006633"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,5,14]]},"abstract":"<jats:p>\n                    Inflammation is a complex immune response driven by oxidative stress and proinflammatory mediators that promote tissue damage and disease progression. Although syncarpic acid exhibits antioxidant therapeutic potential, its clinical utility is limited by suboptimal efficacy and poor pharmacological properties. In the current study, we synthesized novel 4\u2010alkyl\/aryl\u2010syncarpic acid derivatives using organocatalytic reductive\n                    <jats:italic>C<\/jats:italic>\n                    \u2010alkylation and Rh\u2010catalyzed\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010arylation of cyclic iodonium ylides, achieving yields ranging from good to excellent. Furthermore, the antioxidant and anti\u2010inflammatory potential of these compounds was evaluated using the DPPH radical scavenging assay, DCFDA assay, RT\u2010qPCR, and Western blot analysis in RAW 264.7 and BEAS\u20102B cell lines. Our findings demonstrated that compounds\n                    <jats:bold>5c<\/jats:bold>\n                    and\n                    <jats:bold>9a<\/jats:bold>\n                    exhibited markedly higher antioxidant and anti\u2010inflammatory activity compared to other syncarpic acid derivatives. Western blot analysis further revealed that compounds\n                    <jats:bold>5c<\/jats:bold>\n                    and\n                    <jats:bold>9a<\/jats:bold>\n                    exert their anti\u2010inflammatory effects, at least in part, by modulating the MAPK signaling pathway. Acute toxicity studies indicate that compound\n                    <jats:bold>9a<\/jats:bold>\n                    exhibits a favorable safety profile while retaining significant antioxidant activity. Overall, these results indicated that the syncarpic acid derivatives\n                    <jats:bold>5c<\/jats:bold>\n                    and\n                    <jats:bold>9a<\/jats:bold>\n                    exhibit potent anti\u2010inflammatory efficacy and acceptable safety margins, supporting their potential therapeutic application in inflammatory disorders such as acute respiratory distress syndrome (ARDS) and ulcerative colitis.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70306","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:16:47Z","timestamp":1778825807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Evaluation of Novel Syncarpic Acid Derivatives as Potential Anti\u2010Inflammatory Agents"],"prefix":"10.1002","volume":"21","author":[{"given":"Revoju","family":"Sravanthi","sequence":"first","affiliation":[{"name":"Catalysis 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