{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:01:07Z","timestamp":1790798467151,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED431B 2025\/15"],"award-info":[{"award-number":["ED431B 2025\/15"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,5,27]]},"abstract":"<jats:p>\n                    The design of hybrid molecules with multifunctional profiles has emerged as a promising strategy in medicinal chemistry, particularly for tackling complex disorders such as neurodegenerative diseases. There is an urgent need for therapeutic agents capable of acting on multiple pathological targets to both control neuronal death and support the recovery of already compromised neuronal populations. In this study, we synthesized and evaluated a series of hybrid compounds combining a coumarin scaffold with an alkynylamine moiety inspired by rasagiline. These molecules were studied for their potential as human monoamine oxidase (\n                    <jats:italic>h<\/jats:italic>\n                    MAO) inhibitors, antioxidants, and neuroprotective agents. Five compounds demonstrated inhibitory activity against\n                    <jats:italic>h<\/jats:italic>\n                    MAO\u2010B in the micromolar range, along with significant neuroprotective effects against oxidative stress induced by Fe\n                    <jats:sup>3+<\/jats:sup>\n                    (FeNTA),\n                    <jats:italic>tert<\/jats:italic>\n                    \u2010butyl hydroperoxide (\n                    <jats:italic>t<\/jats:italic>\n                    \u2010BHP), and hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ). Additionally, all compounds exhibited the ability to scavenge free radicals (ABTS assay) and chelate Fe(II), further corroborating their antioxidant capacity. In addition, the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties were investigated. Docking studies and molecular dynamics simulations provide additional support for the experimental data. Collectively, these findings provide renewed evidence for the therapeutic potential of coumarin\u2010rasagiline hybrids as multifunctional agents for the treatment of neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70307","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:50:41Z","timestamp":1779162641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design, Synthesis, and Evaluation of Coumarin\u2010Rasagiline Hybrids as Multifunctional Neuroprotective Agents"],"prefix":"10.1002","volume":"21","author":[{"given":"Aitor","family":"Carneiro","sequence":"first","affiliation":[{"name":"Departamento Qu\u00edmica Org\u00e1nica Facultad de Farmacia Universidade de Santiago de Compostela  Santiago de Compostela Spain"},{"name":"Department of Chemistry and Biochemistry Faculty of Sciences University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Barreiro","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Faculty of Sciences University of Porto  Porto Portugal"},{"name":"Associate Laboratory i4HB \u2013 Institute for Health and Bioeconomy Faculty of Pharmacy University of Porto  Porto Portugal"},{"name":"UCIBIO \u2013 Applied Molecular Biosciences Unit, REQUIMTE Laboratory of Toxicology Department of Biological Sciences Faculty of Pharmacy University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Sofia","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Faculty of Sciences University of Porto  Porto Portugal"},{"name":"RISE\u2010Health Faculty of Medicine University of Porto  Porto 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Computational Genomics and Hematology (GreCoXen) Health Research Institute of Santiago de Compostela (IDIS)  Santiago de Compostela Spain"},{"name":"Departamento de Farmacolog\u00eda Farmacia y Tecnolog\u00eda Farmac\u00e9utica Universidade de Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Fernandes","sequence":"additional","affiliation":[{"name":"RISE\u2010Health Faculty of Medicine University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-8299","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Matos","sequence":"additional","affiliation":[{"name":"Departamento Qu\u00edmica Org\u00e1nica Facultad de Farmacia Universidade de Santiago de Compostela  Santiago de Compostela 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