{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T22:01:59Z","timestamp":1780178519448,"version":"3.54.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001322","name":"SAMRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,5,27]]},"abstract":"<jats:p>\n                    Host\u2010directed therapy (HDT) for tuberculosis (TB) generally involves the addition of adjuvant(s) to the standard TB regimen of at least four drugs with the hope of reducing treatment duration. Potential clinical challenges with the addition of adjuvant (s) to the TB regimen are increased pill load, which may lead to nonadherence, and consequently the precipitation of drug resistance; as well as the issue of drug\u2013drug interactions. Molecules that can concurrently act as HDT and antitubercular agent thus have the potential to reduce TB treatment duration, and the pill burden, which may ultimately lead to a simplified TB regimen. To this end, we investigated novel guanilated quinolones as dual inhibitors of Janus Kinase 3 (host target) and Mycobacterium tuberculosis. Compound\n                    <jats:bold>13<\/jats:bold>\n                    was identified with potent Janus Kinase 3 inhibitory activity\u2014exhibiting 98% enzyme inhibition at 1\u2009\u00b5M, and antitubercular activity in the range of 0.2\u20136\u2009\u00b5M in two different growth media.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70319","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:00:36Z","timestamp":1779904836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Guanilated Quinolones with Dual Antitubercular and Anti\u2010Inflammatory Activities"],"prefix":"10.1002","volume":"21","author":[{"given":"Mamorunyane","family":"Morale","sequence":"first","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phelelisiwe S.","family":"Dube","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4752-7400","authenticated-orcid":false,"given":"Audrey","family":"Jordaan","sequence":"additional","affiliation":[{"name":"Molecular Mycobacteriology Research Unit, Department of Pathology and Institute of Infectious Disease and Molecular Medicine University of Cape Town  Observatory South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesetja J.","family":"Legoabe","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4146-0930","authenticated-orcid":false,"given":"Digby F.","family":"Warner","sequence":"additional","affiliation":[{"name":"Molecular Mycobacteriology Research Unit, Department of Pathology and Institute of Infectious Disease and Molecular Medicine University of Cape Town  Observatory South Africa"},{"name":"Wellcome Centre for Infectious Diseases Research in Africa (CIDRI\u2010Africa), Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences University of Cape Town  Observatory South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Allen","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease Research Seattle Children's Research Institute  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Repasy","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease Research Seattle Children's Research Institute  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Parish","sequence":"additional","affiliation":[{"name":"Center for Global Infectious Disease Research Seattle Children's Research Institute  Seattle Washington USA"},{"name":"Department of Tropical Disease Biology Liverpool School of Tropical Medicine  Pembroke Place Liverpool Merseyside UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6282-043X","authenticated-orcid":false,"given":"Richard M.","family":"Beteck","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences North\u2010West University  Potchefstroom South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45491-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2015.05.017"},{"key":"e_1_2_9_4_1","unstructured":"WHO \u201cTB report \u201d2023 accessed November 11 2025 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/tuberculosis."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0444OC"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2019.05.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"a018192","DOI":"10.1101\/cshperspect.a018192","article-title":"Transmission and Institutional Infection Control of Tuberculosis","volume":"6","author":"Nardell E. 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