{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T02:47:48Z","timestamp":1782096468408,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:p>\n                    Pyrazole ribonucleoside analogues were prepared via a linear approach starting with the reaction of D\u2010ribosylhydrazine with 1,3\u2010dicarbonyl or acrylonitrile derivatives, thereby avoiding the regio\u2010 and stereoselectivity challenges typically encountered in\n                    <jats:italic>N<\/jats:italic>\n                    \u2010glycosylation reactions. Three series of pyrazole nucleoside analogues, as along with selected corresponding pronucleotides, were prepared and their antiviral activity against Zika virus and Sars\u2010Cov\u20102 is reported.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70326","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:39:57Z","timestamp":1780987197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Revisiting Hydrazine Moiety as a Scaffold for the Synthesis of Potential Antiviral Pyrazole Ribonucleoside Analogues"],"prefix":"10.1002","volume":"21","author":[{"given":"Ana\u00efs","family":"Guillou","sequence":"first","affiliation":[{"name":"Institut des Biomol\u00e9cules Max Mousseron Universit\u00e9 de Montpellier, CNRS, ENSCM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Gros","sequence":"additional","affiliation":[{"name":"CEMIPAI Universit\u00e9 de Montpellier, CNRS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Muriaux","sequence":"additional","affiliation":[{"name":"CEMIPAI Universit\u00e9 de Montpellier, CNRS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1705-0576","authenticated-orcid":false,"given":"Suzanne","family":"Peyrottes","sequence":"additional","affiliation":[{"name":"Institut des Biomol\u00e9cules Max Mousseron Universit\u00e9 de Montpellier, CNRS, ENSCM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4379-6139","authenticated-orcid":false,"given":"Jean\u2010Jacques","family":"Vasseur","sequence":"additional","affiliation":[{"name":"Institut des Biomol\u00e9cules Max Mousseron Universit\u00e9 de Montpellier, CNRS, ENSCM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8132-7221","authenticated-orcid":false,"given":"Michael","family":"Smietana","sequence":"additional","affiliation":[{"name":"Institut des Biomol\u00e9cules Max Mousseron Universit\u00e9 de Montpellier, CNRS, ENSCM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3114-9361","authenticated-orcid":false,"given":"Christophe","family":"Math\u00e9","sequence":"additional","affiliation":[{"name":"Institut des Biomol\u00e9cules Max Mousseron Universit\u00e9 de Montpellier, CNRS, ENSCM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00102-15"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.1c00070"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105252"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.04.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.11.016"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1QO01936H"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0GC02665D"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/JR9590001648"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25163708"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400234"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1995-4142"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19771100704"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00163a054"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570100639"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19771100705"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.03.016"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00357a020"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570270357"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo0255476"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8GC02860E"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200900289"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo201492m"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw175"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/CPAA.S429064"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1201640"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.109104"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.70326","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T02:12:43Z","timestamp":1782094363000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.70326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6,15]]}},"alternative-id":["10.1002\/cmdc.70326"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.70326","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"2026-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70326"}}