{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T02:47:47Z","timestamp":1782096467580,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:p>\n                    Alzheimer's disease, one of the most widespread neurodegenerative disorders, is known for its multifactorial nature that makes it challenging to treat. In the present work, hybrid molecules were designed and synthesized combining the anti\u2010acetylcholinesterase (AChE) activity of donepezil with the antioxidant and\/or anti\u2010inflammatory activity of selected cinnamic acids. In particular, the new derivatives were conjugated by Steglich esterification or amidation of suitable benzylpiperazine\/piperidine moieties with ferulic, sinapic, 3,4\u2010dimethoxycinnamic acids. All new molecules were evaluated for their activity in terms of AChE inhibition, while molecules that carried a phenolic group were also evaluated for their ability to inhibit lipid peroxidation. A representative group of compounds were studied in vivo for their anti\u2010inflammatory activity with very encouraging results in paw\u2010induced edema in mice. The 3,4\u2010dimethoxycinnamic and sinapic acid esters with a two\u2010carbon linker exhibited the strongest inhibition of AChE with nanomolar values of IC\n                    <jats:sub>50<\/jats:sub>\n                    . In addition, the sinapic esters demonstrated the highest antioxidant and anti\u2010inflammatory activity. Thus, the above results indicate that the new sinapic acid derivatives based on donepezil combine anti\u2010AChE, anti\u2010inflammatory, and antioxidant activities, which warrant their further evaluation as new lead compounds in the treatment of related neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70343","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:24:51Z","timestamp":1781148291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Evaluation of Novel Cinnamic Acid Hybrids With Antiacetylcholinesterase, Antioxidant, and Anti\u2010Inflammatory Properties"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1825-3455","authenticated-orcid":false,"given":"Konstantina","family":"Sdougkou","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Rekka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-8744","authenticated-orcid":false,"given":"Dionysia","family":"Papagiannopoulou","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry School of Pharmacy Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S200490"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3934\/Neuroscience.2021005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2021.03.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.07.327"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27061816"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-023-09021-z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081231"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2024.08.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010024\u201002278\u20108"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-15702-8.00013-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102394"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111357"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113168"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2024.112023"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.796867"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02116-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA03718H"},{"key":"e_1_2_8_20_1","first-page":"1","article-title":"Donepezil: A Review of the Recent Structural Modifications and Their Impact on Anti\u2010Alzheimer Activity","volume":"56","author":"ul A. 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