{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T02:47:47Z","timestamp":1782096467207,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000923","name":"ARC","doi-asserted-by":"publisher","award":["LE0668477"],"award-info":[{"award-number":["LE0668477"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"ARC","doi-asserted-by":"publisher","award":["LE140100119"],"award-info":[{"award-number":["LE140100119"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"ARC","doi-asserted-by":"publisher","award":["LE0237908"],"award-info":[{"award-number":["LE0237908"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"ARC","doi-asserted-by":"publisher","award":["LE230100128"],"award-info":[{"award-number":["LE230100128"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:p>\n                    Caelestines A\u2013D are 2\u2010carboxy\u20104\u2010quinolones (2C4Qs) first isolated from the Australian ascidian\n                    <jats:italic>Aplidium caelestis<\/jats:italic>\n                    . The caelestines are brominated analogues of kynurenic acid and xanthurenic acid, and the only brominated 2C4Qs isolated from nature. A convenient methodology exists for the Conrad synthesis of 2C4Qs from substituted anilines and acetylene dicarboxylates cyclised in Eaton's reagent. This approach yields regioisomers from asymmetric anilines and is hampered by the absence of chromatographic methods for isolation of pure isomers. Here, we report de\u2009novo synthesis of caelestines A\u2013C using this methodology, constituting the first reported syntheses of caelestines B and C, as well as the first reported synthesis of five other novel bromo\u2010quinolones and three related intermediates. The first chromatographic separation of caelestine isomers yielded by Conrad synthesis is described, and structure\u2013activity relationships of caelestines A\u2013C (and related bromo\u2010quinolones) against the\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    3D7 (chloroquine\u2010sensitive) and Dd2 (chloroquine\u2010resistant) strains are elucidated.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70345","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T01:05:06Z","timestamp":1781571906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Total Synthesis and Antimalarial Studies of Caelestines A\u2013C"],"prefix":"10.1002","volume":"21","author":[{"given":"Henry S. T.","family":"Smith","sequence":"first","affiliation":[{"name":"Institute for Biomedicine and Glycomics Griffith University  Nathan Queensland Australia"},{"name":"School of Environment and Science Griffith University  Nathan Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Lock","sequence":"additional","affiliation":[{"name":"School of Environment and Science Griffith University  Nathan Queensland Australia"},{"name":"Discovery Biology Griffith University  Nathan Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky M.","family":"Avery","sequence":"additional","affiliation":[{"name":"School of Environment and Science Griffith University  Nathan Queensland Australia"},{"name":"Discovery Biology Griffith University  Nathan Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4291-7573","authenticated-orcid":false,"given":"Rohan A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine and Glycomics Griffith University  Nathan Queensland Australia"},{"name":"School of Environment and Science Griffith University  Nathan Queensland Australia"},{"name":"NatureBank Griffith University  Nathan Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100329w"},{"key":"e_1_2_9_3_1","volume-title":"Chemical Abstracts 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