{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:46:51Z","timestamp":1782697611249,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,6,26]]},"abstract":"<jats:p>\n                    Cisplatin, carboplatin, and oxaliplatin (OXA) are widely used platinum\u2010based anticancer drugs, but their clinical application is limited by severe adverse effects, including nephrotoxicity, ototoxicity, and neurotoxicity, as well as drug resistance. Oxaliplatin (Eloxatin) is the only platinum compound showing superior clinical efficacy in the treatment of colorectal cancer, yet its use is restricted by dose\u2010dependent toxicity. To address these limitations, OXA and four derivatives were loaded into bacterial ghosts (BGs) as novel drug carriers. BGs derived from the nonpathogenic strains\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    Nissle 1917 (\n                    <jats:italic>EcN<\/jats:italic>\n                    ) and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    NM522 (\n                    <jats:italic>Ec NM522<\/jats:italic>\n                    ) were loaded by simple resuspension and incubation. Platinum content was quantified by inductively coupled plasma mass spectrometry, while the physicochemical properties of the formulations were characterized by fast protein liquid chromatography, transmission and scanning electron microscopy, electron energy\u2010loss spectroscopy, and flow cytometry. The stability of OXA\u2010loaded BG formulations was evaluated in different media and under various storage conditions for up to 120 days. The formulations demonstrated high batch\u2010to\u2010batch reproducibility, and bacterial encapsulation preserved the in vitro anticancer activity of the platinum compounds.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70351","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T01:41:36Z","timestamp":1782438096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bacterial Ghosts as Innovative Transport Vehicles for Platinum\u2010Based Anticancer Drugs"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-6461","authenticated-orcid":false,"given":"Irena","family":"Pashkunova\u2010Martic","sequence":"first","affiliation":[{"name":"Department of Biomedical Imaging and Image\u2010guided Therapy, Division of Molecular and Structural Preclinical Imaging Medical University of Vienna and General Hospital of Vienna  Vienna Austria"},{"name":"Institute of Inorganic Chemistry, Faculty of Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias H. M.","family":"Klose","sequence":"additional","affiliation":[{"name":"Institute of Inorganic Chemistry, Faculty of Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavol","family":"Kudela","sequence":"additional","affiliation":[{"name":"BIRD\u2010C GmbH  Kritzendorf Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Groza\u2010Weber","sequence":"additional","affiliation":[{"name":"Center for Cancer Research Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Reipert","sequence":"additional","affiliation":[{"name":"Core Facility Cell Imaging and Ultrastructure Research University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R.","family":"Kowol","sequence":"additional","affiliation":[{"name":"Institute of Inorganic Chemistry, Faculty of Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6401-8646","authenticated-orcid":false,"given":"Petra","family":"Heffeter","sequence":"additional","affiliation":[{"name":"Center for Cancer Research Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Berger","sequence":"additional","affiliation":[{"name":"Center for Cancer Research Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard K.","family":"Keppler","sequence":"additional","affiliation":[{"name":"Institute of Inorganic Chemistry, Faculty of Chemistry University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Lubitz","sequence":"additional","affiliation":[{"name":"BIRD\u2010C GmbH  Kritzendorf Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.69424"},{"issue":"10","key":"e_1_2_9_3_1","first-page":"372","article-title":"A Phase I Trial of Trans\u20101\u2010Diaminocyclohexane Oxalato\u2010Platinum (l\u2010OHP)","volume":"40","author":"Math\u00e9 G.","year":"1986","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2005.04.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00343"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8dt00838h"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.106261"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108764"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.18\u201000009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155214558350"},{"issue":"4","key":"e_1_2_9_11_1","first-page":"249","article-title":"Management of Oxaliplatin\u2010Induced Peripheral Neuropathy","volume":"1","author":"Saif M. W.","year":"2005","journal-title":"Therapeutics and Clinical Risk Management"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000061"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015495"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10799893.2019.1655050"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.03.028"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2025.07.003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606774"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4161\/bbug.1.5.12540"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124801"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201007\u20102050"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010032712\u2010100008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1424676"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c15237"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033\u2010024\u201001260\u20100"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.077321"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201700753"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201600035"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.70108"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28031086"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2025.113003"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5qi00433k"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25215167"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2015.05.017"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2014.02.014"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.06.072"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2023.2171158"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170201161037"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520621666210805150705"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2020.1737672"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116699"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.07.095"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418\u2010005\u20100780\u20107"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.protis.2016.06.002"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000149782"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.70351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:42:57Z","timestamp":1782697377000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.70351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6,26]]}},"alternative-id":["10.1002\/cmdc.70351"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.70351","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"2026-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70351"}}