{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:46:51Z","timestamp":1782697611293,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277101"],"award-info":[{"award-number":["22277101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,6,26]]},"abstract":"<jats:p>\n                    Structural optimization of natural products provides an important way for new drug discovery. The bioactive natural product\n                    <jats:italic>L<\/jats:italic>\n                    \u2010tetrahydropalmatine and its analogs have attracted significant attention due to their potent pharmacological activities. In this study, a library of novel C12\u2010arylated\n                    <jats:italic>L<\/jats:italic>\n                    \u2010tetrahydropalmatine derivatives (\n                    <jats:bold>4a<\/jats:bold>\n                    \u2013\n                    <jats:bold>4ad<\/jats:bold>\n                    ) was synthesized via Pd\u2010catalyzed Suzuki\u2013Miyaura cross\u2010coupling reaction. Among these derivatives, compound\n                    <jats:bold>4p,<\/jats:bold>\n                    bearing a 4\u2010ethenylphenyl moiety, suppressed the production of pro\u2010inflammatory cytokines (TNF\u2010\u03b1 and IL\u20101\u03b2) in LPS\u2010induced in vitro inflammatory models, indicating that it might be a potential anti\u2010inflammatory agent. This work offers valuable insights into the development of tetrahydropalmatine analogs as novel anti\u2010inflammatory agents.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70355","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:52:17Z","timestamp":1782402737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Anti\u2010Inflammation Activity of C\u201012 Arylated Tetrahydropalmatine Derivatives"],"prefix":"10.1002","volume":"21","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and Engineering Southwest Jiaotong University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and Engineering Southwest Jiaotong University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Sheng","family":"Ji","sequence":"additional","affiliation":[{"name":"Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and Engineering Southwest Jiaotong University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Li","sequence":"additional","affiliation":[{"name":"Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and Engineering Southwest Jiaotong University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Bu","family":"Xu","sequence":"additional","affiliation":[{"name":"Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and Engineering Southwest Jiaotong University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9436-681X","authenticated-orcid":false,"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and Engineering Southwest Jiaotong University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21474"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.9b00916"},{"key":"e_1_2_9_4_1","first-page":"155522","article-title":"Natural Products for the Treatment of Age\u2010Related Macular Degeneration","volume":"130","author":"Wang D. Y.","year":"2024","journal-title":"Phytochemistry"},{"key":"e_1_2_9_5_1","first-page":"155710","article-title":"Natural Products Act as Game\u2010Changer Potentially in Treatment and Management of Sepsis\u2010Mediated Inflammation: A Clinical Perspective","volume":"130","author":"Zhang C.","year":"2024","journal-title":"Phytochemistry"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc202209037"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.890078"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.11.166"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153702"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173397"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-019-05275-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2009.1388"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b18-00037"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155075"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.812148"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201847536"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm000164q"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.101135"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153647"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176883"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1134\/S107042801810010X"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20057528"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2019.01.012"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115027"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.70355","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:42:55Z","timestamp":1782697375000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.70355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6,26]]}},"alternative-id":["10.1002\/cmdc.70355"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.70355","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"2026-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70355"}}