{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:53:44Z","timestamp":1787061224303,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,7,29]]},"abstract":"<jats:p>\n                    Cancer remains a leading cause of mortality, often complicated by drug resistance arising from single\u2010target therapies. Dual inhibitors that simultaneously target multiple cancer\u2010related defense mechanisms offer a promising strategy to overcome these limitations. Herein, we report the design, synthesis, and biological evaluation of a series of sultam\u2010based\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acyl derivatives (\n                    <jats:bold>8a\u2013k<\/jats:bold>\n                    and\n                    <jats:bold>9a\u2013k<\/jats:bold>\n                    ) as potential dual inhibitors of thioredoxin reductase (TrxR1) and tumor\u2010associated carbonic anhydrases (CA IX and XII). TrxR1 screening identified a few active compounds, with inhibitory potency strongly influenced by the type and orientation of substituents. CA inhibition assays revealed pronounced selectivity for CA IX\/XII, while off\u2010target isoforms CA I and CA II remained unaffected. These findings highlight the potential of sultam derivatives as dual\u2010targeting anticancer agents and provide a foundation for further optimization toward selective, multi\u2010pathway cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70359","type":"journal-article","created":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T06:20:40Z","timestamp":1784442040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sultams as Dual Inhibitors of Human Carbonic Anhydrase and Thioredoxin Reductase"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4930-7372","authenticated-orcid":false,"given":"Aleksandrs","family":"Pustenko","sequence":"first","affiliation":[{"name":"Latvian Institute of Organic Synthesis  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raitis","family":"Bobrovs","sequence":"additional","affiliation":[{"name":"Latvian 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