{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:06:02Z","timestamp":1784106362642,"version":"3.55.0"},"reference-count":72,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003947","name":"Universidad Nacional de La Plata","doi-asserted-by":"publisher","award":["X940"],"award-info":[{"award-number":["X940"]}],"id":[{"id":"10.13039\/501100003947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,7,14]]},"abstract":"<jats:p>\n                    Echinococcosis is a neglected tropical disease (NTD) caused by\n                    <jats:italic>Echinococcus granulosus<\/jats:italic>\n                    and\n                    <jats:italic>Echinococcus multilocularis<\/jats:italic>\n                    , the etiological agents of cystic and alveolar echinococcosis, respectively. These infections pose a significant public health burden, particularly in endemic regions. Cestodes lack key enzymes involved in lipid metabolism and must acquire lipids from their hosts. Fatty\u2010acid binding proteins (FABPs), which mediate lipid trafficking and intracellular transport, have therefore emerged as essential and potentially druggable targets. In this study, we implemented an integrated virtual screening strategy combining ligand\u2010based and structure\u2010based approaches to identify novel FABP binders as potential therapeutic agents against\n                    <jats:italic>Echinococcus spp<\/jats:italic>\n                    . High\u2010specificity screening of approximately 435,000 compounds yielded a limited number of prioritized in silico hits. Four compounds\u2014hydrochlorothiazide, naratriptan, fenticonazole, and montelukast\u2014were selected for experimental validation, prioritizing repurposing candidates. Fluorescence displacement assays confirmed that hydrochlorothiazide binds to three cestode FABPs (EgFABP1, EmFABP1, and EmFABP3), validating the predictive performance of the computational workflow. These findings support the value of parallel in silico screening strategies and drug repurposing approaches for the discovery of new therapeutic candidates against NTD.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70364","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:36:12Z","timestamp":1783478172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug Repurposing Against Cestode Fatty Acid Binding Proteins Through Integrated Virtual Screening and In Vitro Validation"],"prefix":"10.1002","volume":"21","author":[{"given":"Santiago","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n y Desarrollo de Bioactivos (LIDeB) Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP)  La Plata Argentina"},{"name":"Instituto de Investigaciones Bioqu\u00edmicas de La Plata (INIBIOLP) Facultad de Ciencias M\u00e9dicas Universidad Nacional de La Plata (UNLP)  La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas N.","family":"Alberca","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n y Desarrollo de Bioactivos (LIDeB) Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP)  La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Gavernet","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n y Desarrollo de Bioactivos (LIDeB) Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP)  La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela R.","family":"Franchini","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Bioqu\u00edmicas de La Plata (INIBIOLP) Facultad de Ciencias M\u00e9dicas Universidad Nacional de La Plata (UNLP)  La Plata 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