{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:03:25Z","timestamp":1785359005115,"version":"3.55.0"},"reference-count":252,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,7,29]]},"abstract":"<jats:p>\n                    Alzheimer's disease (AD) is a complex neurodegenerative disorder involving interconnected pathological pathways, including cholinergic dysfunction, A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    deposition, tau hyperphosphorylation, neuroinflammation, oxidative stress, and dysregulation of metal ion homeostasis. Recently, the \u201cone drug, one target\u201d paradigm has faced certain clinical limitations, driving a paradigm shift toward multi\u2010target therapeutic strategies. In this context, tricyclic scaffolds, characterized by rigid fused\u2010ring skeletons, excellent structural tunability, and favorable neuropharmacological properties, have emerged as promising scaffolds for developing multi\u2010target AD therapeutics. These molecules can interact with multiple AD\u2010related targets through stable \u03c0\u2013\u03c0 stacking and hydrophobic interactions. Some tricyclic scaffolds, such as tetrahydrocarbolines, share structural similarity with endogenous neurotransmitters, suggesting potential involvement in modulating cognitive and mood\u2010related pathways, along with favorable BBB permeability and neuro\u2010compatibility. Accordingly, this review begins by outlining the distinct pathological mechanisms underlying AD, followed by a summary of recent progress on tricyclic compounds, encompassing both single\u2010target and multi\u2010target\u2010directed molecules, with an emphasis on structure\u2013activity relationships and mechanisms of action, aiming to offer new insights and strategies for combating this devastating disease.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70384","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:46:11Z","timestamp":1784252771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Tricyclic Compounds for the Treatment of Alzheimer's Disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Yichun","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry Key Laboratory of Drug\u2010Targeting and Drug Delivery System of the Education Ministry and Sichuan Province West China School of Pharmacy Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindan","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Materials China Academy of Engineering Physics  Mianyang Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9767-6825","authenticated-orcid":false,"given":"Guangjun","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Materials China Academy of Engineering Physics  Mianyang Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010025\u201008186\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155101"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.0301"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520410048025"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115219"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.952211"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad159"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1080753"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.07.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X22666240308090741"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115295"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c01042"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000381\u20106"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1573034"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867329666220408102051"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527322666230519113201"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14372"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169305"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.23"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156209"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115489"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557520999201209211610"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7058341"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105192"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1245"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2021.11.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/127984"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010022\u201001191\u2010x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010023\u201000792\u20104"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673\u20105374.2012.22.005"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.106141"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.2c01150"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010021\u201002725\u20106"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.28"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13632"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.01.001"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2023.10.002"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmr.2025.100053"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S235969"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201003509\u20100"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3232"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007680\u2010x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27020883"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001484\u20107"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010018\u20101918\u20108"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2408"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.6.2739"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010180868"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010052919\u2010120219"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010020\u201000376\u20106"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201026851\u20102"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271221102519"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u20100687\u20106"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adp2564"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.616029"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010021\u201000070\u20102"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000523\u2010w"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207663"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002326\u20103"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2019.367"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25687"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.55680"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202400462"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1351792"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.178154"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272\u2010023\u201001463\u20100"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.09.001"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101619"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.994018"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.2024.39.S1.2465"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264\u2010013\u20101423\u2010y"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10525"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527319666200722153611"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1496661"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010015\u20100157\u2010y"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70455"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173552"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.01.017"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010024\u201001104\u20107"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.01.015"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.371360"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.04.022"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00271"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.05.058"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.02.001"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030540"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm6131"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010024\u201001664\u2010w"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111651"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200785"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201011674\u2010z"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.05.017"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1451032"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406223211063020"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2022.12.003"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0663\u201024.2024"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010230772"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2022"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010020\u201000189\u2010z"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00248"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3158\u201009.2009"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8134"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009335\u2010x"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(08)70167\u20104"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809057106"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c03049"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.117198"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14638"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096\u2010024\u201001730\u20100"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1221069"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4161"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201000995\u20109"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100708"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17030280"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.02.035"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S236922"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867329666220328125206"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001911\u20103"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.09.006"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095\u20108137.2022.289"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119596"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00502"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00545"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.6b00184"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00391"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103312"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.0c00466"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00015a002"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm049309"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1035"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.02.030"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201500104"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009\u20108981(78)90322\u20104"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.02.071"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512799361691"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113604"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156609"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.20289"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm300598e"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802608783334024"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.20288"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0109\u201020"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.114330"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi200026m"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.02.080"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.04.104"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00774"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010022\u201000754\u20108"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/35102591"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.06.020"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896\u20106273(03)00840\u20107"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209085200"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113705"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104020(03)00687\u20102"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3012189"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.976799"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217697"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00096"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107787"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.11.018"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432\u20101327.2000.01219.x"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn4002208"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2np00068g"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c00214"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118530"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3qo02000b"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106375"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.01.012"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00191"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00242"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.5"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.950480"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14205"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0864\u201009.2009"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00979"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901519f"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301189c"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4mb00389f"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.08.027"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113321"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.10.005"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986707779940998"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01887"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026619666191203113745"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019264"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1021\/np060092r"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2085"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.04.003"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00358"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.02.007"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113815"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm100842v"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2024.129670"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116624"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113554"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.114095"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133328"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010019\u20100165\u20100"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2024.109941"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.4c00153"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c06344"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2022.910427"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.07.014"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527321666220422085835"},{"key":"e_1_2_9_211_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010019\u201002538\u2010y"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176750"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115257"},{"key":"e_1_2_9_214_1","doi-asserted-by":"publisher","DOI":"10.1021\/np200591h"},{"key":"e_1_2_9_215_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c01363"},{"key":"e_1_2_9_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106595"},{"key":"e_1_2_9_217_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205018666211208140551"},{"key":"e_1_2_9_218_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2024.2419827"},{"key":"e_1_2_9_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.10.046"},{"key":"e_1_2_9_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.101178"},{"key":"e_1_2_9_221_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm100064d"},{"key":"e_1_2_9_222_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn4002126"},{"key":"e_1_2_9_223_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00699"},{"key":"e_1_2_9_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.06.048"},{"key":"e_1_2_9_225_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021717"},{"key":"e_1_2_9_226_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180403151725"},{"key":"e_1_2_9_227_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X16666180412091908"},{"key":"e_1_2_9_228_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557523666221201145141"},{"key":"e_1_2_9_229_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm300124p"},{"key":"e_1_2_9_230_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00528"},{"key":"e_1_2_9_231_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00184"},{"key":"e_1_2_9_232_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010020\u201000854\u20101"},{"key":"e_1_2_9_233_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb1206"},{"key":"e_1_2_9_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2018.11.001"},{"key":"e_1_2_9_235_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20191209"},{"key":"e_1_2_9_236_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c02150"},{"key":"e_1_2_9_237_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010016\u20100399\u20103"},{"key":"e_1_2_9_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.08.020"},{"key":"e_1_2_9_239_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav0316"},{"key":"e_1_2_9_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpet.2020.12.003"},{"key":"e_1_2_9_241_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01482"},{"key":"e_1_2_9_242_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c03368"},{"key":"e_1_2_9_243_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5MD00274E"},{"key":"e_1_2_9_244_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00011"},{"key":"e_1_2_9_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.05.001"},{"key":"e_1_2_9_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.01.037"},{"key":"e_1_2_9_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103997"},{"key":"e_1_2_9_248_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14010033"},{"key":"e_1_2_9_249_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3790728"},{"key":"e_1_2_9_250_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13332"},{"key":"e_1_2_9_251_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00624"},{"key":"e_1_2_9_252_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21968"},{"key":"e_1_2_9_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.117201"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.70384","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T20:28:24Z","timestamp":1785356904000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.70384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":252,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,7,29]]}},"alternative-id":["10.1002\/cmdc.70384"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.70384","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"assertion":[{"value":"2026-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70384"}}