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Although antibiotics such as carbapenems and polymyxins are used to treat\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    infections, the emergence of multidrug\u2010resistant\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    has greatly limited treatment options. Thus,\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    infections are regarded as a great threat to global health. Previously, we successfully introduced the\n                    <jats:italic>laeA<\/jats:italic>\n                    gene into fungal strains in order to significantly increase the production of secondary metabolites, allowing us to create an original library (the\n                    <jats:styled-content>\n                      <jats:italic>\u014c<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>mura<\/jats:italic>\n                    <jats:styled-content>\n                      <jats:italic>L<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>aeA\u2010Introduced<\/jats:italic>\n                    <jats:styled-content>\n                      <jats:italic>Fungal<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:styled-content>\n                      <jats:italic>\u014cLF<\/jats:italic>\n                    <\/jats:styled-content>\n                    )\n                    <jats:italic>library<\/jats:italic>\n                    ) and discover novel biological activities. In this study, we aimed to discover antibacterial compounds against\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    from the\n                    <jats:italic>\u014cLF<\/jats:italic>\n                    library. Following the screening program, 3\u2010chlorogentisyl alcohol (\n                    <jats:bold>1<\/jats:bold>\n                    ) was isolated from the\n                    <jats:italic>Penicillium concentricum<\/jats:italic>\n                    KTF\u20100317 strain, which produced the compound in higher amounts than the corresponding wild\u2010type strain. Our investigations found that\n                    <jats:bold>1<\/jats:bold>\n                    demonstrated strong antibacterial activity even against quinolone \u2010 resistant\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    strain. However, difficulties were encountered in the purification of natural compound\n                    <jats:bold>1<\/jats:bold>\n                    . Therefore, synthetic samples were prepared via total synthesis and supplied for biological evaluation, enabling clarification of the structure\u2013activity relationships. Our innovative approach revealed the overlooked biological activity of\n                    <jats:bold>1<\/jats:bold>\n                    and showed the prolificity and usefulness of the\n                    <jats:italic>\u014cLF<\/jats:italic>\n                    library.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70388","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T01:46:14Z","timestamp":1784511974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Unified Strategy Based on\n                    <i>laeA<\/i>\n                    Gene Introduction and Synthetic Approaches for Rediscovery of 3\u2010Chlorogentisyl Alcohol as an Antibacterial Compound Against\n                    <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1002","volume":"21","author":[{"given":"Sota","family":"Honma","sequence":"first","affiliation":[{"name":"Graduate School of Infection 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