{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:03:23Z","timestamp":1785359003523,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,7,29]]},"abstract":"<jats:p>\n                    In a recent study, the oxadiazin\u20105\u2010one\u2010based compound\n                    <jats:bold>CJ1\u201034<\/jats:bold>\n                    was identified as a partial ATP synthase inhibitor, which was found to bind the F\n                    <jats:sub>1<\/jats:sub>\n                    region of the ATP synthase. These findings were used as a starting point for the design and synthesis of smaller heterocycles, such as pyrazolidine\u20103\u2010ones and pyrazol\u20103\u2010ones, as novel structural scaffolds for potential ATP synthase inhibitors. Among the newly synthesized compounds, pyrazolidin\u20103\u2010one derivatives\n                    <jats:bold>9a<\/jats:bold>\n                    and\n                    <jats:bold>10a<\/jats:bold>\n                    outperformed the lead compound\n                    <jats:bold>CJ1\u201034<\/jats:bold>\n                    in vitro by inhibiting ATP hydrolytic activity and decreasing ATP levels in HT\u201022 cells. Subsequent dose\u2010dependent studies identified compound\n                    <jats:bold>9a<\/jats:bold>\n                    as the most promising ATP synthase inhibitor. Molecular docking revealed similar binding modes for all compounds in the F1\u2010binding site and the calculated docking scores aligned with the measured IC\n                    <jats:sub>50<\/jats:sub>\n                    values of the tested compounds. This study identified pyrazolidine\u20103\u2010ones as promising structural scaffolds for ATP synthase inhibition, opening avenues for further biomedical applications in central nervous system diseases such as Alzheimer's and Parkinson's.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70399","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:29:41Z","timestamp":1785205781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Pyrazolidine\u20103\u2010One Derivatives as a Novel Structural Scaffold for ATP Synthase Inhibitors"],"prefix":"10.1002","volume":"21","author":[{"given":"Lisa","family":"Reichert","sequence":"first","affiliation":[{"name":"Department of Chemistry and Applied Biosciences Institute of Pharmaceutical Sciences ETH Z\u00fcrich  Zurich 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