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A combination of light\u2010controlled chemotherapy (PACT) and PDT in one molecule has the potential to overcome crucial drawbacks of both Pt\u2010based chemotherapy and PDT via a synergetic effect. Herein, we report a Pt(IV)\u2010BODIPY agent for dual light\u2010controlled chemophotodynamic therapy, a Pt(IV) prodrug with a BODIPY orthogonal dimer in the axial position. The orthogonal arrangement of the fluorophores results in a long\u2010lived, \u201cheavy\u2010atom\u2010free\u201d triplet state of the dimeric fluorophore. The high quantum yield of singlet oxygen for the dimer fluorophore and the Pt(IV) prodrug based on it was confirmed, and the formation of the triplet state was demonstrated by flash photolysis. The excellent photosensitive properties of the Pt(IV) prodrug on SK\u2010BR\u20103 and MCF\u20107 tumor cells demonstrate photocontrolled toxicity and potential for the development of dual therapy conjugates.<\/jats:p>","DOI":"10.1002\/cmdc.70412","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:01:32Z","timestamp":1785495692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heavy\u2010Atom\u2010Free Dual\u2010Action Dual PACT\/PDT action Pt(IV) Prodrug With BODIPY Dimer in Axial Position"],"prefix":"10.1002","volume":"21","author":[{"given":"Vladislav","family":"Bykusov","sequence":"first","affiliation":[{"name":"Chemistry Department Lomonosov Moscow State University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Isaeva","sequence":"additional","affiliation":[{"name":"Chemistry Department Lomonosov Moscow State University  Moscow Russia"},{"name":"Enikolopov Institute of Synthetic Polymer Materials RAS  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Akasov","sequence":"additional","affiliation":[{"name":"Enikolopov Institute of Synthetic Polymer Materials RAS  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Egorova","sequence":"additional","affiliation":[{"name":"Department of Bio\u0441hemistry Petrovsky Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8299-9595","authenticated-orcid":false,"given":"Valerii","family":"Mun","sequence":"additional","affiliation":[{"name":"N.K. 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