{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:54:41Z","timestamp":1791438881473,"version":"4.3.3"},"reference-count":43,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["IF210360"],"award-info":[{"award-number":["IF210360"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:p>\n                    A novel and facile method for the synthesis of unnatural \u03b2\u2010pyridonyl \u03b1\u2010amino acid derivatives via hydroamination of dehydroalanine (Dha) with 2\u2010 and 4\u2010hydroxypyridine was described. The reaction of\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010diprotected Dha with 2\u2010 and 4\u2010hydroxypyrdine proceeded smoothly at room temperature to afford a variety of 2\u2010 and 4\u2010pyridonyl amino acids, whereas the reaction of mono\n                    <jats:italic>N<\/jats:italic>\n                    \u2010protected Dha with 2\u2010 and 4\u2010hydroxypyridine reacted at 80\u2009\u00b0C heating to give corresponding pyridonyl amino acid derivatives. Further, a new family of deuterated \u03b2\u2010pyridonyl \u03b1\u2010amino acid derivatives has been synthesized using D\n                    <jats:sub>2<\/jats:sub>\n                    O as cosolvent. The hydroamination method has been extented to Dha\u2010containing small peptides. The antimicrobial evaluation of the synthesized compounds demonstrated moderate inhibitory activity against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Micrococcus luteus<\/jats:italic>\n                    , and\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    , along with antifungal activity against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    . Further, in vitro evaluation revealed that the six synthesized compounds exhibit notable anti\u2010inflammatory potential in murine macrophages, as evidenced by high production of the anti\u2010inflammatory cytokine (IL\u201010) and minimal release of pro\u2010inflammatory cytokines (IL\u20101\u03b2 and TNF\u2010\u03b1). Overall, this strategy provides a straightforward approach to structurally diverse pyridonyl amino acids with promising applications in drug discovery, particularly for inflammatory disorders.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70415","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T04:32:19Z","timestamp":1786163539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydroamination of Dehydroalanine With Deuterium Incorporation to Access Unnatural 2\u2010 and 4\u2010Pyridonyl \u03b1\u2010Amino Acids: Evaluation of Their Antibacterial, Antifungal, and Immunomodulatory Activities"],"prefix":"10.1002","volume":"21","author":[{"given":"Sowmya B.","family":"Udayakumar","sequence":"first","affiliation":[{"name":"Department of Organic Synthesis and Process Chemistry CSIR\u2010Indian Institute of Chemical Technology  Hyderabad India"},{"name":"Academy of Scientific and 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