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A novel class of glucosidase inhibitors based on aminocyclitols was synthesized using a new method. This method involves arranging the\n                    <jats:italic>\u03b1\u2010<\/jats:italic>\n                    ,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010unsaturated structure by attacking the ammonia compound on the acetate group in the\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010position forming, to form the amide in the\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010position. The method has enabled the synthesis of new types of C\n                    <jats:sub>8<\/jats:sub>\n                    N, such as C\n                    <jats:sub>7<\/jats:sub>\n                    N (C\n                    <jats:sub>8<\/jats:sub>\n                    N generally exhibits structural and characteristic biological properties similar to C\n                    <jats:sub>7<\/jats:sub>\n                    N) compounds. After purification and structure elucidation of the resulting substances,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010glucosidase, and amylase tests were performed against acarbose; additionally, an enzyme kinetic study of well\u2010active compounds was conducted. Subsequently, the anticancer activity of substances was analyzed using a viability assay and AO\/PI staining. Our results suggest that different derivatives of new carbosugar isomers exert potential enzymatic and anticancer activity against breast cancer cells.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70422","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T02:31:26Z","timestamp":1786847486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inducing Metabolic Dysfunction in Breast Cancer Cells Through Targeted Inhibition of\n                    <i>\u03b1<\/i>\n                    \u2010 and\n                    <i>\u03b2<\/i>\n                    \u2010Glucosidase and Amylase: Novel Carbohydrate (C\n                    <sub>8<\/sub>\n                    N) Isomers Designed via Intramolecular\n                    <i>aza<\/i>\n                    \u2010Michael\u2010Type Reaction"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8447-2851","authenticated-orcid":false,"given":"Emel","family":"Karak\u0131l\u0131\u00e7","sequence":"first","affiliation":[{"name":"Department of Chemistry Science Faculty Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-2091","authenticated-orcid":false,"given":"G\u00f6kay","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Karamanoglu Mehmetbey University Vocational School of Health Services  Karaman Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2088-9914","authenticated-orcid":false,"given":"Gamze G\u00fcney","family":"Eskiler","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Faculty of Medicine Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6311-1918","authenticated-orcid":false,"given":"Sinan","family":"Ba\u015f\u00e7eken","sequence":"additional","affiliation":[{"name":"Department of Chemistry Science Faculty Hitit University  \u00c7orum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-5099","authenticated-orcid":false,"given":"Arif","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Chemistry Science Faculty Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr1004138"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo050521a"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0404085"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104039(01)00612\u20108"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/np070210q"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo300444b"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol3028237"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065\u20102318(08)60031\u20101"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","unstructured":"T.Suami \u201cChemistry of Pseudo-Sugars\u201d inCarbohydrate Chemistry(Springer 1990) 257\u2013283 https:\/\/doi.org\/10.1007\/BFb0111563.","DOI":"10.1007\/BFb0111563"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9403300"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076\u20106879(94)47011\u20101"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076\u20106879(94)47010\u20103"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol100525r"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b00133"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/b205561a"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2011.07.009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200800238"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201702371"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2008.07.049"},{"key":"e_1_2_11_21_1","first-page":"313","article-title":"Molecular Detection of \u03b1\u2010Glucosidase Inhibitor\u2010Producing Actinomycetes","volume":"43","author":"Hyun C. 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