{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:28:18Z","timestamp":1787772498967,"version":"build-2784847793"},"reference-count":153,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministry for Universities and Research, Italy","doi-asserted-by":"publisher","award":["Grant Project no. PE00000007, INF\u2010ACT, Spoke 5"],"award-info":[{"award-number":["Grant Project no. PE00000007, INF\u2010ACT, Spoke 5"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministry for Universities and Research, Italy","doi-asserted-by":"publisher","award":["Project code 20228NPP2Y"],"award-info":[{"award-number":["Project code 20228NPP2Y"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University of Rome","doi-asserted-by":"publisher","award":["Ateneo 2024 (project code RG124190BB0EB5C9)"],"award-info":[{"award-number":["Ateneo 2024 (project code RG124190BB0EB5C9)"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:p>Given its pivotal role in the viral life cycle, blocking integrase (IN) through IN strand transfer inhibitors (INSTIs) represented a breakthrough in the treatment of HIV infection, establishing these antiretroviral regimens as first\u2010line options against AIDS. However, the onset of drug\u2010resistant strains has challenged the efficacy of INSTIs, demanding new efforts in the search for therapeutic tools that work through alternative modes of action. In this context, the discovery of allosteric IN inhibitors (ALLINIs) has highlighted new opportunities to target IN beyond its active site, enhancing antiviral efficacy and the genetic barrier to resistance. Extensive drug discovery campaigns have resulted in the development of effective ALLINIs with both in vitro and in vivo efficacy, two of which are advancing in clinical trials as next\u2010generation therapeutic tools. Nevertheless, advancements in structural biology have critically aided in elucidating the underlying effects of ALLINIs, highlighting a complex, multimodal mode of action that ultimately yields defects in virion maturation. This review focuses on ALLINIs, providing a comprehensive overview of major drug discovery efforts devoted to this field, with an emphasis on the medicinal chemistry and structural biology findings that have revealed unprecedented opportunities for developing innovative and effective anti\u2010HIV drugs.<\/jats:p>","DOI":"10.1002\/cmdc.70428","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T03:50:46Z","timestamp":1787457046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2907-5503","authenticated-orcid":false,"given":"Francesco","family":"Saccoliti","sequence":"first","affiliation":[{"name":"Department of Life Science Health and Health Professions Link Campus University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4531-3612","authenticated-orcid":false,"given":"Elisa","family":"Patacchini","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Istituto Pasteur\u2010Fondazione Cenci Bolognetti \u201cSapienza\u201d Universit\u00e0 di Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7723-2201","authenticated-orcid":false,"given":"Emanuele","family":"Cara","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Istituto Pasteur\u2010Fondazione Cenci Bolognetti \u201cSapienza\u201d Universit\u00e0 di Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3724-4133","authenticated-orcid":false,"given":"Laura","family":"Zarbo","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Istituto Pasteur\u2010Fondazione Cenci Bolognetti \u201cSapienza\u201d Universit\u00e0 di Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0158-5816","authenticated-orcid":false,"given":"Antonella","family":"Messore","sequence":"additional","affiliation":[{"name":"Department of Life Science Health and Health Professions Link Campus University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6850-528X","authenticated-orcid":false,"given":"Aurora","family":"Albano","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Istituto Pasteur\u2010Fondazione Cenci Bolognetti \u201cSapienza\u201d Universit\u00e0 di Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3911-6833","authenticated-orcid":false,"given":"Giuseppe","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Istituto Pasteur\u2010Fondazione Cenci Bolognetti \u201cSapienza\u201d Universit\u00e0 di Roma  Rome Italy"},{"name":"Dottorato di Interesse Nazionale in One Health Approaches to Infectious Diseases and Life Science Research Dipartimento di Sanit\u00e0 Pubblica Medicina Sperimentale e Forense Universit\u00e0 degli Studi di Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-612X","authenticated-orcid":false,"given":"Valentina Noemi","family":"Madia","sequence":"additional","affiliation":[{"name":"Department of Science Roma Tre University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-7005","authenticated-orcid":false,"given":"Luigi","family":"Scipione","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Istituto Pasteur\u2010Fondazione Cenci Bolognetti \u201cSapienza\u201d Universit\u00e0 di Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1314-9029","authenticated-orcid":false,"given":"Roberta","family":"Costi","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Istituto Pasteur\u2010Fondazione Cenci Bolognetti \u201cSapienza\u201d Universit\u00e0 di Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4279-7666","authenticated-orcid":false,"given":"Roberto","family":"Di Santo","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologie del Farmaco Istituto Pasteur\u2010Fondazione Cenci Bolognetti \u201cSapienza\u201d Universit\u00e0 di Roma  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010025\u201002181\u20101"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization HIV Data and Statistics accessed May 7 2026 https:\/\/www.who.int\/teams\/global\u2010hiv\u2010hepatitis\u2010and\u2010stis\u2010programmes\/hiv\/strategic\u2010information\/hiv\u2010data\u2010and\u2010statistics."},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization HIV and AIDS accessed May 7 2026 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/hiv\u2010aids."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13020205"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113787"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118190"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jve.2025.100608"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaf488"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2024.107294"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20105247(20)30006\u20109"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.enz.2021.06.007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010021\u201000586\u20109"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14050926"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.04.029"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00861\u201023"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11020100"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2017.0004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/586401"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328666210322164557"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00125"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01754"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah5163"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105078"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08784"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09517"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16955"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16950"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002346107"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.03.027"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV119.006901"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay8015"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay4919"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.06.003"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.118"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.17.9524\u20109537.2004"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010008\u20107540\u20105"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.104671"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506924102"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7101-5_72"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411681200"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14091883"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.09.033"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303594200"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1064896"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400674a"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.011008.145553"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.15.12.1507"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711796504619"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501799k"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.09.008"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20104690\u201010\u201087"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm800245z"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.1.97"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1397"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712799320565"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01534\u201007"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2011.586631"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06618\u201011"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3010459"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.073189"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301550c"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400645w"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.24543"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01474\u201016"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00157\u201011"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02406\u201020"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph12020062"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103018(23)00136\u20104"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010021\u201001005\u20101"},{"key":"e_1_2_9_71_1","unstructured":"World Health Organization WHO Recommends Long\u2010Acting Cabotegravir for HIV Prevention accessed May 8 2026 https:\/\/www.who.int\/news\/item\/28\u201007\u20102022\u2010who\u2010recommends\u2010long\u2010acting\u2010cabotegravir\u2010for\u2010hiv\u2010prevention."},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977\u2010018\u20100420\u20107"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab276"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz256"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkae085"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2025.04.002"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977\u2010017\u20100360\u20107"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1051096"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000443"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.370"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1329"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1565107"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/v1030780"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.10.094"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501378200"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030047"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb937"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002558"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2013.04.010"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00397\u201009"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21169"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.443390"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00486\u201020"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444901001652"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.132"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2012.10.002"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1039\/B810306B"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16020200"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.2002"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.354373"},{"key":"e_1_2_9_101_1","unstructured":"C.Fenwick S.Tremblay E.Wardrop et al. \u201cResistance Studies With HIV\u20101 Non\u2010Catalytic Site Integrase Inhibitors\u201d Poster presented at the International Workshop on HIV & Hepatitis Virus Drug Resistance and Curative Strategies (Los Cabos 2011) https:\/\/doi.org\/10.13140\/RG.2.2.34042.06089."},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004171"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.347534"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00717\u201012"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.816793"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20104690\u201010\u2010144"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml500002n"},{"key":"e_1_2_9_108_1","unstructured":"Y. S.Tsantrizos M.Boes C.Brochu et al. \u201cInhibitors of Human Immunodeficiency Virus Replication \u201d International Patent Application WO 2007\/131350 A1 (2007)."},{"key":"e_1_2_9_109_1","unstructured":"Y. S.Tsantrizos M. D.Bailey F.Bilodeau et al. \u201cInhibitors of Human Immunodeficiency Virus Replication \u201d International Patent Application WO 2009\/062285 A1 (2009)."},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks913"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300703110"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074163"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01522\u201015"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.4155\/fsoa\u20102018\u20100060"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14071466"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02719\u201013"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011097"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46344"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.551119"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.6b00194"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml500110j"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977\u2010017\u20100373\u20102"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1177\/135965350701200411"},{"issue":"1","key":"e_1_2_9_124_1","first-page":"17","article-title":"Characterization and Structural Analysis of HIV\u20101 Integrase Conservation","volume":"11","author":"Ceccherini\u2010Silberstein F.","year":"2009","journal-title":"AIDS Reviews"},{"key":"e_1_2_9_125_1","unstructured":"M.De La Rosa S. N.Haydar B. A.Johns andE. J.Velthuisen \u201cIsoquinoline Compounds and Methods for Treating HIV \u201d International Patent Application WO 2012\/102985 (2012)."},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002584"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.13.6057"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1074\/j"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.589572"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2997"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014\u20105793(96)01236\u20107"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.5.3507\u20103514.1997"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2025.169224"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2020.12.001"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.044"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54311"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02328\u201020"},{"key":"e_1_2_9_139_1","volume-title":"Poster presented at the Conference on Retroviruses and Opportunistic Infections (CROI)","author":"Mitchell M.","year":"2017"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009671"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00465\u201024"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00462\u201023"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfab073"},{"key":"e_1_2_9_144_1","unstructured":"ClinicalTrials.gov U.S. National Library of Medicine A Clinical Trial of STP0404 in Adults With HIV\u20101 Infection accessed May14 2025 https:\/\/clinicaltrials.gov\/study\/NCT05869643."},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaf695.002"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03560\u201022"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2025.07.005"},{"key":"e_1_2_9_148_1","unstructured":"ClinicalTrials.gov U.S. National Library of Medicine Single Ascending Dose Trial Investigating Safety Tolerability and Pharmacokinetics of BDM\u20102 in Healthy Male Subjects accessed June 17 2020 https:\/\/clinicaltrials.gov\/study\/NCT03634085."},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.4c00268"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0511583"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00535"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm5001503"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00159"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010026\u201010154\u2010x"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.70428","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:52:22Z","timestamp":1787770342000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.70428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":153,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8,27]]}},"alternative-id":["10.1002\/cmdc.70428"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.70428","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]},"assertion":[{"value":"2026-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70428"}}