{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:28:15Z","timestamp":1787772495028,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404470"],"award-info":[{"award-number":["82404470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC1731"],"award-info":[{"award-number":["2025ZNSFSC1731"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2682026CX101"],"award-info":[{"award-number":["2682026CX101"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:p>\n                    To explore natural\u2010inspired novel anti\u2010AD bioactive molecules, a series of galantamine derivatives\n                    <jats:bold>6a<\/jats:bold>\n                    \u2013\n                    <jats:bold>6u<\/jats:bold>\n                    were synthesized via Pd\u2010catalyzed Buchwald\u2013Hartwig cross\u2010coupling, with various nitrogen\u2010containing functional groups installed at the C3 position of galantamine. Compared with galantamine, these compounds showed greatly enhanced selective BChE inhibition activity, suggesting that the C3 position of galantamine might be a key modifiable site for developing new selective BChE inhibitors. Among them, the derivative\n                    <jats:bold>6l<\/jats:bold>\n                    which contained a 3,5\u2010difluoroaniline structure moiety exhibited promising selective inhibitory activity against\n                    <jats:italic>eq<\/jats:italic>\n                    BChE, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 0.88\u2009\u03bcM and a selectivity index of 26.2. Molecular docking and molecular dynamics simulations were performed to elucidate the interaction model between compound\n                    <jats:bold>6l<\/jats:bold>\n                    and BChE. Moreover,\n                    <jats:bold>6l<\/jats:bold>\n                    also showed favorable neuroprotection potency against H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    injured SH\u2010SY5Y cells. Preliminary mechanistic study revealed that compound\n                    <jats:bold>6l<\/jats:bold>\n                    could mitigate oxidative stress and suppress cellular apoptosis. This work not only offers a novel galantamine analog with promising in vitro cholinesterase inhibitory and neuroprotective effects for further anti\u2010AD study, but also provides new insights into the structure optimization of natural drug galantamine.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70431","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T01:44:58Z","timestamp":1786844698000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel C3\u2010Aminated Galantamine Derivatives as Selective Butyrylcholinesterase Inhibitors With Neuroprotective Effects"],"prefix":"10.1002","volume":"21","author":[{"given":"Fu\u2010Lian","family":"Tang","sequence":"first","affiliation":[{"name":"Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and Engineering Southwest Jiaotong University  Chengdu P. R. 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