{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:54:41Z","timestamp":1791438881518,"version":"4.3.3"},"reference-count":51,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:p>\n                    A series of hybrid molecules containing indole and 1,3,5\u2010triazine scaffolds was synthesized and evaluated for their antiviral activity against several human RNA and DNA viruses. The conjugates displayed overall low cytotoxicity (CC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009&gt;\u200950\u2009\u00b5M) and potent antiviral activity across a coronavirus panel, with the most promising analogs (compounds\n                    <jats:bold>5d<\/jats:bold>\n                    ,\n                    <jats:bold>5g<\/jats:bold>\n                    and\n                    <jats:bold>5o<\/jats:bold>\n                    ) showing sub\u2010 to low\u2010micromolar EC\n                    <jats:sub>50<\/jats:sub>\n                    values against HCoV\u2010OC43, HCoV\u2010229E, and SARS\u2010CoV\u20102. Structure\u2010activity relationship studies highlighted that the substitution pattern on the anilino moiety allowed to modulate antiviral activity. Time\u2010of\u2010drug addition, adsorption, and fusion assays indicated inhibition of viral replication at an early viral entry step, consistent with inhibition of spike\u2010mediated membrane fusion. Overall, these data suggest that 1,3,5\u2010triazine\u2010indole conjugates are a promising scaffold to develop broad\u2010spectrum coronavirus entry inhibitors. ADMET profiling of lead compounds (\n                    <jats:bold>5d, 5g,<\/jats:bold>\n                    and\n                    <jats:bold>5o<\/jats:bold>\n                    )\u00a0revealed favorable pharmacokinetic properties, including high oral absorption, limited CNS penetration, and non\u2010mutagenic safety profiles.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70434","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:38:18Z","timestamp":1786592298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of 1,3,5\u2010Triazine\u2010Indole Conjugates as Broad\u2010Spectrum Coronavirus Entry Inhibitors"],"prefix":"10.1002","volume":"21","author":[{"given":"Shazia","family":"Asghar","sequence":"first","affiliation":[{"name":"Department of Chemistry Quaid\u2010I\u2010Azam University  Islamabad 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Research, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-1153","authenticated-orcid":false,"given":"Dirk","family":"Daelemans","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation Rega Institute for Medical Research, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-6558","authenticated-orcid":false,"given":"Steven De","family":"Jonghe","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation Rega Institute for Medical Research, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, KU Leuven  Leuven 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