{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:28:16Z","timestamp":1787772496042,"version":"build-2784847793"},"reference-count":71,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:p>\n                    Five novel series of isatin\u2013Schiff base derivatives (\n                    <jats:bold>1a\u20135e<\/jats:bold>\n                    ) were synthesized, and their neuroprotective and anti\u2010infective potential was evaluated. Their half\u2010maximal inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) was determined against both monoamine oxidase A (MAO\u2010A) and MAO\u2010B targets for the treatment of depression and Parkinson's disease, respectively. The anti\u2010infective potential of the synthesized derivatives was evaluated by measuring their IC\n                    <jats:sub>50<\/jats:sub>\n                    values against urease, an enzyme utilized by specific pathogenic bacteria as a virulence factor. The minimum inhibitory concentration for each compound was assessed against a panel of human pathogens. Most derivatives had potent in vitro activity against MAO\u2010A and MAO\u2010B, even greater than the positive control, isatin. The 4\u2010chloroisatin substituted series (\n                    <jats:bold>2a<\/jats:bold>\n                    \u2013\n                    <jats:bold>d<\/jats:bold>\n                    ) showed exceptional MAO\u2010A inhibition (\n                    <jats:bold>2d<\/jats:bold>\n                    : 0.040\u2009\u00b1\u20090.002\u2009\u00b5M), while the unsubstituted, 5\u2010, 6\u2010, and 7\u2010chloroisatin analogues (\n                    <jats:bold>1a<\/jats:bold>\n                    \u2013\n                    <jats:bold>e<\/jats:bold>\n                    ,\n                    <jats:bold>3a<\/jats:bold>\n                    \u2013\n                    <jats:bold>c<\/jats:bold>\n                    ,\n                    <jats:bold>4a<\/jats:bold>\n                    \u2013\n                    <jats:bold>b<\/jats:bold>\n                    , and\n                    <jats:bold>5a<\/jats:bold>\n                    \u2013\n                    <jats:bold>e<\/jats:bold>\n                    ) demonstrated high potency and selectivity toward MAO\u2010B, the most active being\n                    <jats:bold>5d<\/jats:bold>\n                    (0.018\u2009\u00b1\u20090.003\u2009\u00b5M; selectivity index\u2009=\u200915\u2009389). Kinetic analysis confirmed a competitive and reversible mode of inhibition. None of the derivatives showed urease inhibition or significant antibacterial activity. These findings highlight the isatin\u2013Schiff base derivatives as promising agents for potent and selective MAO inhibitors with therapeutic potential for neurodegenerative disorders.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70437","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T01:59:09Z","timestamp":1786845549000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Novel Isatin\u2013Schiff Base Derivatives: Monoamine Oxidase Inhibition and Antimicrobial Assessment"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7633-8707","authenticated-orcid":false,"given":"Marthinus J.","family":"Jooste","sequence":"first","affiliation":[{"name":"Centre of Excellence for Pharmaceutical Sciences North\u2010West University  Potchefstroom South 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