{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:28:14Z","timestamp":1787772494981,"version":"build-2784847793"},"reference-count":85,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a multifactorial neurodegenerative disorder and the leading cause of dementia among the elderly worldwide. In medicinal chemistry and drug discovery, heterocycles are widely recognized as privileged scaffolds due to their structural versatility and biological relevance. In the context of AD, heterocyclic compounds have been extensively investigated for the development of potential therapeutic agents. Among fused heterocyclic systems, oxygen\u2010, nitrogen\u2010, and sulfur\u2010containing heterocycles are particularly prominent in approved drugs. This review focuses on recent advances in the exploration of xanthone derivatives, alongside with their nitrogen\u2010 and sulfur\u2010containing analogs, as promising template scaffolds for the development of prospective anti\u2010AD therapeutics.<\/jats:p>","DOI":"10.1002\/cmdc.70453","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:49:16Z","timestamp":1787762956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Xanthones and Their Nitrogen and Sulfur Analogs in Alzheimer\u2019s Disease: Recent Progress Toward Multifunctional Therapeutics"],"prefix":"10.1002","volume":"21","author":[{"given":"Daniela","family":"Malafaia","sequence":"first","affiliation":[{"name":"LAQV\u2010REQUIMTE &amp; Department of Chemistry University of Aveiro  Aveiro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia","family":"Melo","sequence":"additional","affiliation":[{"name":"LAQV\u2010REQUIMTE &amp; Department of Chemistry University of Aveiro  Aveiro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur M. 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