{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:28:22Z","timestamp":1787772502004,"version":"build-2784847793"},"reference-count":54,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:p>\n                    A new series of combretastatin A4\u2010chalcone hybrids were designed and synthesized to explore their potential as cytotoxic agents. The compounds were evaluated for cytotoxic activity, tubulin inhibition, and anti\u2010angiogenic properties. The designed hybrids exhibited significant cytotoxic effects across all the tested cancer cell lines. Among them, two compounds,\n                    <jats:bold>5d<\/jats:bold>\n                    and\n                    <jats:bold>5o<\/jats:bold>\n                    , exhibited potent cytotoxicity, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.02 and 0.03\u2009\u03bcM, respectively, against the prostate cancer\u20103 cell line. Further biological investigations suggested that treatment with\n                    <jats:bold>5d<\/jats:bold>\n                    and\n                    <jats:bold>5o<\/jats:bold>\n                    induces apoptosis, as evidenced by Hoechst 33\u2009342 staining, Rhodamine 123 staining, MitoSOX red assays, and cell migration assays. Flow cytometric analysis revealed that both compounds caused dose\u2010dependent G2\/M phase cell cycle arrest in PC\u20103 cells. Their ability to inhibit tubulin polymerization was further confirmed through immunofluorescence assays. Additionally, molecular docking studies provided insights into their interaction profiles at the molecular level. Collectively, these findings highlight\n                    <jats:bold>5d<\/jats:bold>\n                    and\n                    <jats:bold>5o<\/jats:bold>\n                    as promising lead molecules with potential for further development in anticancer drug discovery.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70456","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:01:16Z","timestamp":1787763676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and Synthesis of Combretastatin A4\u2010Chalcone Hybrids as Tubulin Polymerization Inhibitors"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0318-5445","authenticated-orcid":false,"given":"Chetna","family":"Jadala","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad India"},{"name":"Indiana University (IU)  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa Reddy","family":"Telukutla","sequence":"additional","affiliation":[{"name":"Centre for Advanced Materials &amp; Industrial Chemistry (CAMIC) School of Science RMIT University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5054-2519","authenticated-orcid":false,"given":"Ganga Reddy","family":"Velma","sequence":"additional","affiliation":[{"name":"Centre for Advanced Materials &amp; Industrial Chemistry (CAMIC) School of Science RMIT University  Melbourne Australia"},{"name":"Department of Pharmacology and Toxicology R Ken Coit College of Pharmacy University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmya","family":"Dastari","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"Tokala","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad India"},{"name":"Athinoula A. Martinos Centre for Biomedical Imaging Department of Radiology Massachusetts General Hospital Harvard Medical School  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi Tulasi","family":"Naraharisetti","sequence":"additional","affiliation":[{"name":"National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandraiah","family":"Godugu","sequence":"additional","affiliation":[{"name":"National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9298-5112","authenticated-orcid":false,"given":"Suresh K.","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Centre for Advanced Materials &amp; Industrial Chemistry (CAMIC) School of Science RMIT University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6889-3667","authenticated-orcid":false,"given":"Magdalena","family":"Plebanski","sequence":"additional","affiliation":[{"name":"Accelerator for Translational Research in Clinical Trials (ATRACT) Centre School of Health and Biomedical Sciences STEM College RMIT University  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagula","family":"Shankaraiah","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4107-1775","authenticated-orcid":false,"given":"Ahmed","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad India"},{"name":"Department of Chemistry Osmania University  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/mog2.46","article-title":"Microtubule\u2010targeting Agents for Cancer Treatment: Seven Binding Sites and Three Strategies","volume":"2","author":"Wang X.","year":"2023","journal-title":"MedComm \u2013 Oncology"},{"issue":"3","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2478\/aiht-2019-70-3258","article-title":"An Overview of Microtubule Targeting Agents for Cancer Therapy","volume":"70","author":"Karahalil B.","year":"2019","journal-title":"Archives of Industrial Hygiene and Toxicology"},{"issue":"2","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1158\/1535-7163.MCT-13-0791","article-title":"Targeting Microtubules by Natural Agents for Cancer Therapy","volume":"13","author":"Mukhtar E.","year":"2014","journal-title":"Molecular Cancer Therapeutics"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"940239","DOI":"10.3389\/fonc.2022.940239","article-title":"A Systemic Review of Taxanes and Their Side Effects in Metastatic Breast Cancer","volume":"12","author":"Lai J. 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