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Compounds\n                    <jats:bold>7a<\/jats:bold>\n                    \u2013\n                    <jats:bold>j<\/jats:bold>\n                    were obtained via a semiconvergent synthetic route employing copper\u2010catalyzed azide\u2013alkyne cycloaddition (click chemistry), yielding the target molecules in moderate to good yields. Biological activity was assessed through vascular reactivity assays using rat aortic rings in the presence of angiotensin II. Most compounds reduced angiotensin II\u2010induced contraction, consistent with a putative AT\n                    <jats:sub>1<\/jats:sub>\n                    receptor antagonist profile. Among them, compound\n                    <jats:bold>7f<\/jats:bold>\n                    , bearing a methylenedioxyphenyl substituent, exhibited the most favorable biological profile within the series. The results indicate that electron\u2010donating groups favor activity, while strongly electron\u2010withdrawing substituents, such as nitro, are detrimental. Molecular docking studies predicted consistent interactions with key residues, particularly Arg167 and Tyr87, providing a plausible structural rationale for the observed biological activity. In silico ADME predictions indicated acceptable drug\u2010like properties, including compliance with drug\u2010likeness filters and a predicted bioavailability score, and no blood\u2013brain barrier permeation.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70460","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:45:28Z","timestamp":1788234328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxadiazolone\u2010Triazole Derivatives as a New Scaffold for Modulation of Angiotensin II\u2010Induced Vascular Contraction"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5347-3858","authenticated-orcid":false,"given":"Larissa F. 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A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Vit\u00f3ria Academic Centre (CAV) Federal University of Pernambuco (UFPE)  Vit\u00f3ria de Santo Ant\u00e3o Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jivaldo G.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Vit\u00f3ria Academic Centre (CAV) Federal University of Pernambuco (UFPE)  Vit\u00f3ria de Santo Ant\u00e3o Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9728-8033","authenticated-orcid":false,"given":"Alice V.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Vit\u00f3ria Academic Centre (CAV) Federal University of Pernambuco (UFPE)  Vit\u00f3ria de Santo Ant\u00e3o Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-8284","authenticated-orcid":false,"given":"Jana\u00edna V. dos","family":"Anjos","sequence":"additional","affiliation":[{"name":"Department of Fundamental Chemistry Federal University of Pernambuco (UFPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"Global Report on Hypertension 2025: High Stakes \u2010 Turning Evidence Into Action","volume":"01","author":"WHO","year":"2025","journal-title":"World Health Organization"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/life15010087"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32461-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.55522\/jmpas.V12I1.4280"},{"key":"e_1_2_9_7_1","first-page":"341","article-title":"Managing Hypertension Using Combination Therapy","volume":"101","author":"Smith D. 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