{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:48:24Z","timestamp":1792003704855,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,10,14]]},"abstract":"<jats:p>\n                    In this study, we describe the synthesis of new 1\u2010(1\u2010benzyl\u20102\u2010oxoindolin\u20103\u2010ylidene)\u20104\u2010(3\u2010sulfamoylphenyl)thiosemicarbazides and evaluate their inhibitory activity against hCAs (\n                    <jats:bold>6a\u2013l<\/jats:bold>\n                    ). The inhibitory effects of compounds\n                    <jats:bold>6a\u2013l<\/jats:bold>\n                    were examined in vitro against hCA I, II, IX, and XII isoforms. Acetazolamide (AAZ) was employed as the standard reference compound in this study. The compounds\n                    <jats:bold>6a\u2013l<\/jats:bold>\n                    inhibited the tumor\u2010associated hCA IX and XII isoenzymes at nanomolar levels, and showed weak inhibitory effects on the off\u2010target hCA I and II isoenzymes. Selectivity index (SI) values of compounds\n                    <jats:bold>6a\u2013l<\/jats:bold>\n                    were determined to be significantly high for hCA IX and XII over hCA I and II compared to AAZ. Compound\n                    <jats:bold>6k<\/jats:bold>\n                    (R\n                    <jats:sub>1<\/jats:sub>\n                    \u2009=\u2009Cl, R\n                    <jats:sub>2<\/jats:sub>\n                    \u2009=\u20093\u2010Cl) showed the strongest inhibitory effect (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>i<\/jats:italic>\n                    <\/jats:sub>\n                    \u2009=\u200925.23\u2009nM) and high selectivity (SI\u2009=\u2009225, 185) against hCA IX over hCA I and II. Compound\n                    <jats:bold>6f<\/jats:bold>\n                    (R\n                    <jats:sub>1<\/jats:sub>\n                    \u2009=\u2009CH\n                    <jats:sub>3<\/jats:sub>\n                    , R\n                    <jats:sub>2<\/jats:sub>\n                    \u2009=\u20094\u2010Cl) was found to have the highest inhibitory effect (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>i<\/jats:italic>\n                    <\/jats:sub>\n                    \u2009=\u200936.65\u2009nM) and high selectivity (SI\u2009=\u2009377 and 192, respectively) against hCA XII over hCA I and II. Molecular docking and dynamic simulation analyses were conducted to explore how compounds\n                    <jats:bold>6f<\/jats:bold>\n                    and\n                    <jats:bold>6k<\/jats:bold>\n                    interact with active sites of hCA XII and IX enzymes.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70467","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:21:29Z","timestamp":1791789689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Moleculer Modeling, and Carbonic Anhydrase Inhibitor Effects of Novel 1\u2010(1\u2010benzyl\u20102\u2010oxoindolin\u20103\u2010ylidene)\u20104\u2010(3\u2010sulfamoylphenyl)thiosemicarbazides"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-9389","authenticated-orcid":false,"given":"\u00c7a\u011fla Beg\u00fcm","family":"Apayd\u0131n","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5625-0189","authenticated-orcid":false,"given":"Tu\u011f\u00e7e","family":"Cinek","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Istanbul Health and Technology University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0536-4212","authenticated-orcid":false,"given":"Hayrunnisa","family":"Nadaro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Food Technology Vocational College of Technical Sciences Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-122X","authenticated-orcid":false,"given":"Nilg\u00fcn","family":"Karal\u0131","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.05.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2023.129411"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.10.5.575"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm001051"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1475636021000010950"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.06.054"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.08.048"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072560"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202200148"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm101541x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-025-00690-z"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.10.005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5OB00688K"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.01.030"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.10.068"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.07.054"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103514"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103635"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.05.029"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202200023"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118509"},{"key":"e_1_2_7_25_1","unstructured":"N.Karal\u0131 F.G\u00f6kta\u015f G.Cihan \u00dcst\u00fcnda\u011f andP.Eraslan Elma \u201cNew 1\u2010Substituted 1H\u2010Indole\u20102 3\u2010Dione Derivatives and Synthesis Methods \u201d Turkish Patent Application TR 2015 015912 B."},{"key":"e_1_2_7_26_1","first-page":"438","article-title":"Organic Thiocyanate Compounds. 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