{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:08:26Z","timestamp":1789348106499,"version":"build-2803163510"},"reference-count":167,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:p>Cancer remains a major global health challenge, and the limited efficacy, systemic toxicity, multidrug resistance, and tumor recurrence associated with current therapies continue to drive the development of novel targeted anticancer agents. Quinoline\u2010based heterocyclic scaffolds have emerged as valuable structural frameworks in anticancer drug discovery owing to their structural diversity and ability to interact with multiple oncogenic targets. This review provides a target\u2010oriented overview of quinoline\u2010based anticancer agents reported between 2019 and 2025, covering quinoline, quinazoline, quinoxaline, and a few selected nonquinoline nitrogen\u2010containing heterocyclic derivatives. Recent advances in quinoline\u2010based derivatives targeting ER, CDK4\/6, topoisomerase I\/II, epidermal growth factor receptor, PLC\u03b31, PI3K\/AKT, and VEGFR\u20102\/P\u2010glycoprotein pathways are discussed with respect to their synthetic strategies, in vitro anticancer assay, and structure\u2013activity relationships (SAR). This review integrates comparative SAR trends across diverse quinoline\u2010based scaffolds, highlighting the influence of scaffold planarity, ring fusion, substitution patterns, linker architecture, and metal complexation on anticancer activity. In addition, clinically approved quinoline\u2010based anticancer drugs, representative patents, and future perspectives are summarized to emphasize the translational potential of these scaffolds. Collectively, this review provides a comprehensive overview of recent advances to guide the rational design of next\u2010generation quinoline\u2010based anticancer agents.<\/jats:p>","DOI":"10.1002\/cmdc.70472","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:42:11Z","timestamp":1787881331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quinoline\u2010Based Scaffolds in Anticancer Drug Discovery: Molecular Targets, Synthetic Strategies, and Biological Advances"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9285-3474","authenticated-orcid":false,"given":"Amir","family":"Raza","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Lovely Professional University  Phagwara Punjab India"},{"name":"CT College of Pharmacy CT Group of Institutions  Jalandhar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-2749","authenticated-orcid":false,"given":"Pankaj","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"Ummeed Institute of Pharmaceutical Sciences and Research Centre  Sri Ganganagar Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9928-9953","authenticated-orcid":false,"given":"Shivani","family":"Sharma","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Lovely Professional University  Phagwara Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/10732748211038735"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-28780-0_60"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14020280"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci8010018"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-02198-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01102-y"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-025-01562-3"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152011797927634"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-800-3_2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-025-01713-y"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14060589"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00558-5"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061809-100002"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16040680"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2020.1821676"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520620666200705214917"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-023-08809-3"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-815720-6.00002-2"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00101.2014"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28304"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3MA00621B"},{"key":"e_1_2_12_23_1","volume-title":"Unlocking the Therapeutic Potential of RNA: A Comprehensive Review of RNA\u2010Based Therapy","author":"Ahmad R. U.","year":"2023"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-025-02782-6"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15194689"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076834"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.587386"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2024.14839"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz586"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.147216"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2014.912836"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-36"},{"key":"e_1_2_12_33_1","volume-title":"Mechanisms of Hormonal Activation of Cdc25A and Coactivation of Estrogen Receptor Alpha by Protein Inhibitor of Activated STAT3 (PIAS3)","author":"Lee W.\u2010R.","year":"2009"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157812"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574884711308020006"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1872"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031242"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21061960"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30165-3"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.020"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168391"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.6.4.515"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062935"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00840-4"},{"key":"e_1_2_12_45_1","volume-title":"Molecular Mechanisms Maintaining Cell Cycle Arrest Induced by Pharmacological CDK4\/6 Inhibition","author":"Mouery B. L.","year":"2024"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1467033"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2607"},{"key":"e_1_2_12_48_1","first-page":"1","article-title":"Targeting Epigenetic and DNA Topology Mechanisms: Histone Deacetylases and Topoisomerase Inhibitors in Combination and Dual Inhibition Approaches","volume":"78","author":"Reddy Y.","year":"2026","journal-title":"Pharmacological Reports"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-091724-010717"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-7041-1_7"},{"key":"e_1_2_12_51_1","volume-title":"Genetics 101: From Chromosomes and the Double Helix to Cloning and DNA Tests, Everything You Need to Know About Genes","author":"Skwarecki B.","year":"2018"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.968302"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.899009"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2025.1704789"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043986"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13307"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05406-y"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr258"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01657-y"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900026u"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26052018"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2608"},{"key":"e_1_2_12_63_1","volume-title":"Structure and Function of DNA Topoisomerase II Beta","author":"Ling E. M.","year":"2023"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.71330"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof10090629"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00325"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.15567"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1161"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-3005-6_15"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01828"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1443"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.52711\/2231-5659.2021-11-2-14"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2619"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10110859"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210789941865"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.22543\/7674.71.P3439"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22647"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568009611313030002"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14071652"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.852383"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-025-05462-1"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101870"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-2043-3"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.3306"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.620214"},{"key":"e_1_2_12_86_1","volume-title":"Effects of CDK4\/6 Inhibitor\u2010Induced Stromal Senescence on the Metastatic Niche and Metastasis of Breast Cancer","author":"Gallanis G. T.","year":"2023"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.33594\/000000512"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.23.648"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194562"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0044-1"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176424"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202401051"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14221804"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2026.01.012"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1080\/17568919.2024.2380243"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers18040578"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2024.110689"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201903718"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00315-x"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16020299"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01162"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115734064278334231211054053"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25081909"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.69613\/yj37ha36"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21795"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5MD00849B"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00392"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.2174\/18741045-v16-e2209010"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30173646"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-025-00801-6"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091242"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557516666161031121639"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.2174\/0122127968335169250107180240"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.2174\/0109298673344501250109210447"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026621666210527103225"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.1004465"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200417154810"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA03281C"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.1017"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-02657-2"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.22039"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00178C"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200916852"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.70059"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616666160506145943"},{"key":"e_1_2_12_126_1","first-page":"634","article-title":"New Anti\u2010Breast Cancer Drug Palbociclib","volume":"39","author":"Shu X. J. L.","year":"2015","journal-title":"Advances in Pharmaceutical Sciences"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci200463r"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955705774933329"},{"key":"e_1_2_12_129_1","unstructured":"S.Rampalli L. K.Upalla S.Cherukuvada C. B.Patneedi G. K.Dasari andV. M. M. R.Seshagiri Polymorphs of Ribociclib Mono Succinate (Google Patents 2021)."},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0840-z"},{"key":"e_1_2_12_131_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.18601\/16571959.n22.08","article-title":"Caso Imatinib: An\u00e1lisis T\u00e9cnico Y Jur\u00eddico Del Tr\u00e1mite De Patente En Colombia (Imatinib Case: Technical and Legal Analysis of Patent Prosecution in Colombia","volume":"22","author":"Pinilla L. D.","year":"2016","journal-title":"Revista La Propiedad Inmaterial"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-91439-8_12"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713137"},{"key":"e_1_2_12_134_1","volume-title":"Crystal of Salt of 4\u2010(3\u2010Chloro\u20104\u2010(Cyclopropylaminocarbonyl)aminophenoxy)\u20107\u2010Methoxy\u20106\u2010Quinolinecarboxamide or of Solvate Thereof","author":"Matsushima T.","year":"2009"},{"key":"e_1_2_12_135_1","volume-title":"4\u2010Anilino\u20103\u2010Quinolinecarbonitriles for the Treatment of Chronic Myelogenous Leukemia (CML)","author":"Boschelli D. H.","year":"2008"},{"key":"e_1_2_12_136_1","volume-title":"c\u2010Met Modulators and Methods of Use","author":"Bannen L. J.","year":"2009"},{"key":"e_1_2_12_137_1","volume-title":"Protein Tyrosine Kinase Enzyme Inhibitors","author":"Wissner A.","year":"2008"},{"key":"e_1_2_12_138_1","unstructured":"J. D. C. D. G.Hangauer J.Gale J. A.Cody et al. Process for the Preparation of Compositions for Modulating a Kinase Cascade and Methods of use Thereof (US8293739B2 2012)."},{"key":"e_1_2_12_139_1","first-page":"1","volume-title":"US\u20105770599\u2010A, Quinazoline Derivatives","author":"Hopkinson G. K.","year":"1998"},{"key":"e_1_2_12_140_1","unstructured":"S. C. L.Jeffrey U.Lau Seagen Inc. \u201cCamptothecin Conjugates \u201d (U.S. Patent January 14 2025) 12."},{"key":"e_1_2_12_141_1","unstructured":"D. C. K.Drummond B.D. A. M.Awad et al. Stabilizing Camptothecin Pharmaceutical Compositions (U.S. Patent August 13 2024) 12 059 497 B052."},{"key":"e_1_2_12_142_1","unstructured":"R. J. M.Barvian J. Q.Booth J. T.Repine et al. 2\u2010(Pyridin\u20102\u2010ylamino)\u2010Pyrido[2 3\u2010d]pyrimidin\u20107\u2010Ones(U.S.P.a.T. Office (Ed.) Warner Lambert Co LLC 2005)."},{"key":"e_1_2_12_143_1","volume-title":"Pyrrolopyrimidine Compounds and Their Uses","author":"Brain M. J. S. C. T.","year":"2013"},{"key":"e_1_2_12_144_1","volume-title":"Catheter With Tissue Protecting Assembly","author":"Phan D. K. S. H. D.","year":"2014"},{"key":"e_1_2_12_145_1","volume-title":"Heterocyclic Compounds and Uses Thereof","author":"Castro K. C. A. C.","year":"2015"},{"key":"e_1_2_12_146_1","volume-title":"Therapeutic Combination of Quinoline Derivative and Antibody","author":"L. Chia Tai Tianqing Pharmaceutical Group Co","year":"2025"},{"key":"e_1_2_12_147_1","unstructured":"J.Zimmermann Pyrimidine Derivatives and Processes for the Preparation Thereo (Google Patents 1996)."},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-019-02467-6"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.5539\/ijc.v12n1p99"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26164899"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15040399"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2136172"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13738-022-02704-7"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30885-5"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103406"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000002"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2024.101359"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-021-01530-w"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747519819861389"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000237"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0274081"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104255"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104399"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15070781"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914590"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2025.118434"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.815531"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28114537"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.70472","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.70472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:46:05Z","timestamp":1789346765000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.70472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":167,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9,14]]}},"alternative-id":["10.1002\/cmdc.70472"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.70472","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"2026-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70472"}}