{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:08:38Z","timestamp":1789348118524,"version":"build-2803163510"},"reference-count":72,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:p>\n                    Prion diseases are neurodegenerative disorders caused by the accumulation of misfolded prion proteins, leading to neurotoxicity and neuronal death. Creutzfeldt\u2010Jakob disease (CJD) in humans and Bovine spongiform encephalopathy (BSE) in animals are among the most prominent prion disorders. Therefore, the search for molecules that can serve as drugs for prion diseases has gained significant attention. In our study, we synthesised and characterised two piano\u2010stool ruthenium complexes, RuBT and RuBI, based on benzazole\u2010quinoline scaffolds. Molecular structures of RuBT and RuBI were determined by X\u2010ray crystallography. The anti\u2010aggregation effects of the complexes on PrP\n                    <jats:sub>106\u2013126<\/jats:sub>\n                    aggregation were studied through ThT assay, CD, TEM, and AFM. Seeded aggregation assays demonstrated their ability to modulate seed\u2010induced fibril formation. The interaction between the complexes and PrP\n                    <jats:sub>106\u2013126<\/jats:sub>\n                    was analysed using molecular docking and UV\u2013visible spectroscopy. Molecular docking analysis showed good binding affinity with the PrP\n                    <jats:sub>106\u2013126<\/jats:sub>\n                    . To demonstrate bioavailability and transport, the DNA and HSA binding affinities of complexes were computed. The complexes exhibited neuroprotective effects in HT\u201022 cells by reducing damage induced by PrP\n                    <jats:sub>106\u2013126<\/jats:sub>\n                    . They also showed anticancer activity on human neuroblastoma SH\u2010SY5Y cells. These findings suggest that these complexes facilitate future studies on full\u2010length prion proteins and advanced disease models.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70480","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:40:01Z","timestamp":1788982801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Piano\u2010Stool Ru (II) Complexes as Modulators of Human Prion Protein PrP\n                    <sub>106\u2013126<\/sub>\n                    Aggregation"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5438-3112","authenticated-orcid":false,"given":"Rahul","family":"Chauhan","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee Uttarakhand 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India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3395-9482","authenticated-orcid":false,"given":"Prashant","family":"Kukreti","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Medda","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioengineering Indian Institute of Technology Roorkee  Roorkee Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1943-3079","authenticated-orcid":false,"given":"Partha","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioengineering Indian Institute of Technology Roorkee  Roorkee Uttarakhand 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Numbers 2513850 (for RuBT) and 2513851 (for RuBI) Contain the Supplementary Crystallographic Data for This 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