{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:57:10Z","timestamp":1790567830798,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018227","name":"National Research Foundation of Ukraine","doi-asserted-by":"publisher","award":["2025.07\/0168"],"award-info":[{"award-number":["2025.07\/0168"]}],"id":[{"id":"10.13039\/100018227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,9,28]]},"abstract":"<jats:p>\n                    A library of 16 new five\u2010functionalized derivatives of 2\u2010undecyl\u2010 and 1,2,4\u2010oxadiazole\u2010containing 2\u2010aryl\u20104\u2010cyano\u20101,3\u2010oxazoles was synthesized using\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010acylamino\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010dichloroacrylonitriles as key building blocks, enabling efficient formation of diverse 1,3\u2010oxazole, oxadiazole\u2013oxazole, and sulfonamide\u2013oxazole systems. The antiviral potential was evaluated in vitro against rhinovirus 8 (HRV8), cytomegalovirus (HCMV), parainfluenza virus type 3 (HPIV\u20103), and zoonotic encephalomyocarditis virus (EMCV). Screening revealed distinct activity profiles: none of the compounds inhibited EMCV or HPIV\u20103, while several demonstrated pronounced efficacy against HRV8 and HCMV. In concentration\u2010dependent assays, compounds\n                    <jats:bold>1, 7, 10, 13<\/jats:bold>\n                    <jats:bold>,<\/jats:bold>\n                    and\n                    <jats:bold>14<\/jats:bold>\n                    exhibited potent anti\u2010HCMV effects (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20090.42\u20134.67\u2009\u00b5M). Compound\n                    <jats:bold>7<\/jats:bold>\n                    showed remarkable selectivity (SI\u2009=\u2009465), outperforming ganciclovir (GCV, SI\u2009=\u2009326). Against HRV8, compound\n                    <jats:bold>2<\/jats:bold>\n                    was the most active (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20091.67\u2009\u00b5M, SI\u2009=\u200911), whereas compound\n                    <jats:bold>13<\/jats:bold>\n                    displayed weak activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200921.0\u2009\u00b5M, SI\u2009=\u20091). All molecules met drug\u2010likeness criteria with favorable ADMET\u2010predicted pharmacokinetic parameters. Molecular docking suggested that derivatives\n                    <jats:bold>7, 10, 13<\/jats:bold>\n                    <jats:bold>,<\/jats:bold>\n                    and\n                    <jats:bold>14<\/jats:bold>\n                    may target viral DNA polymerase, with binding energies from \u20138.8 to \u20139.7\u2009kcal\u2009mol\n                    <jats:sup>\u22121<\/jats:sup>\n                    . These findings demonstrate that 1,3\u2010oxazoles represent a promising chemotype for new antiviral candidates active against HCMV and HRV8.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70491","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:01:08Z","timestamp":1789538468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New 1,3\u2010Oxazole and 1,2,4\u2010Oxadiazole Derivatives as Novel Agents Against Human Rhinovirus and Cytomegalovirus"],"prefix":"10.1002","volume":"21","author":[{"given":"Yelyzaveta Yu.","family":"Rybina","sequence":"first","affiliation":[{"name":"Department of Chemistry of Bioactive Nitrogen\u2010Containing Heterocyclic Bases V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry National Academy of Science of Ukraine  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1517-4807","authenticated-orcid":false,"given":"Maryna V.","family":"Kachaeva","sequence":"additional","affiliation":[{"name":"Department of Chemistry of Bioactive Nitrogen\u2010Containing Heterocyclic Bases V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry National Academy of Science of Ukraine  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4628-9017","authenticated-orcid":false,"given":"Agnieszka B.","family":"Olejniczak","sequence":"additional","affiliation":[{"name":"Screening Laboratory Institute of Medical Biology Polish Academy of Sciences  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4379-0367","authenticated-orcid":false,"given":"Marta","family":"Denel\u2010Bobrowska","sequence":"additional","affiliation":[{"name":"Screening Laboratory Institute of Medical Biology Polish Academy of Sciences  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-7124","authenticated-orcid":false,"given":"Victor V.","family":"Zhirnov","sequence":"additional","affiliation":[{"name":"Department of Chemistry of Bioactive Nitrogen\u2010Containing Heterocyclic Bases V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry National Academy of Science of Ukraine  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8464-3692","authenticated-orcid":false,"given":"Ivan V.","family":"Semenyuta","sequence":"additional","affiliation":[{"name":"Department of Chemistry of Bioactive Nitrogen\u2010Containing Heterocyclic Bases V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry National Academy of Science of Ukraine  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-1393","authenticated-orcid":false,"given":"Stepan G.","family":"Pilyo","sequence":"additional","affiliation":[{"name":"Department of Chemistry of Bioactive Nitrogen\u2010Containing Heterocyclic Bases V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry National Academy of Science of Ukraine  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114136"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030\u2010021\u201010375\u20104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117935"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2021.1865309"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1636978"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00009\u201010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11102372"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000170"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13050817"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149\u20102918(95)80107\u20103"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010019\u201002388\u20109"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010020\u201002595\u20102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.33263\/LIANBS132.089"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/1062936X.2023.2232992"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.202300221"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022\u20101317\u201075\u20102\u2010353"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007050170144"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745\u20104565.1982.tb00429.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.1.27"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aihch.2015.05.001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573409918666220404100022"},{"key":"e_1_2_9_23_1","first-page":"1278","article-title":"Reaction of \u03b1\u2010Acylamino\u2010\u03b2,\u03b2\u2010Dichloroacrylonitriles With Primary Amines","volume":"10","author":"Drach B. 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