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Consequently, the development of new therapies, especially potential molecules that focus on specific viral mechanisms to block viral replication, became a critical challenge in recent decades. The Reverse Transcriptase (RT) is an RNA\u2010 and DNA\u2010dependent DNA polymerase enzyme that is responsible for transcribing viral RNA into double\u2010stranded DNA. Non\u2010nucleoside RT Inhibitors perform important role in HIV therapy, and they are responsible for inhibiting RT by blocking its allosteric site, which shows physico\u2010chemical properties such as high hydrophobicity and key amino acid\u2010to\u2010hydrogen bond interactions. For this reason, designing new molecules with innovative heterocycles compatible with these characteristics can provide new potential inhibitors. For example, pentacyclic heterocycles like thiazole and its derivatives like thiazolidinedione, which have physico\u2010chemical properties that can interact with the allosteric site of RT, can be a new perspective in designing new Non\u2010nucleoside RT Inhibitors. 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