{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:48:22Z","timestamp":1792003702956,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,10,14]]},"abstract":"<jats:p>\n                    Conventional nanozymes are generally reported to have\u00a0a symmetric coordination environment near the active centers that can hinder electron transfer and result in limited catalytic efficiency. In a recent article by Na Na and colleagues, an axial sulfur\u2010bridged Mo\u2013S\u2013Cu (A\u2010CuN\n                    <jats:sub>3<\/jats:sub>\n                    S\n                    <jats:sub>1<\/jats:sub>\n                    @MoS\n                    <jats:sub>\n                      2\u2212\n                      <jats:italic>x<\/jats:italic>\n                    <\/jats:sub>\n                    ) nanozyme is developed that functions by utilizing an expanded asymmetric local electric field (LEF). The innovative structure significantly ramps up multienzymatic activities, which include catalase\u2010, peroxidase\u2010, and oxidase\u2010like functions, while concomitantly depleting glutathione. As this nanozyme specifically targets mitochondria in tumors, it initiates a cascade of reactive oxygen species (ROS), activating combined ferroptosis and gasdermin E (GSDME)\u2010mediated pyroptosis. We highlight these findings on how the axial\u2010bridging strategy offers a sophisticated design for nonapoptotic tumor therapy through the modalities of coordination chemistry and electronic structure modulation.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70500","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:27:54Z","timestamp":1791786474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanozymes in Action: Inbuilt Asymmetric Local Electric Field for Enhanced Ferroptosis\u2010Pyroptosis Therapy"],"prefix":"10.1002","volume":"21","author":[{"given":"Huidrom","family":"Mangalsana","sequence":"first","affiliation":[{"name":"Inorganic and Physical Chemistry Laboratory (IPCL) CSIR\u2010Central Leather Research Institute (CLRI)  Chennai Tamil Nadu India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 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