{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:48:24Z","timestamp":1792003704244,"version":"4.4.0"},"reference-count":59,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009327","name":"PAZY Foundation","doi-asserted-by":"publisher","award":["490\u201023"],"award-info":[{"award-number":["490\u201023"]}],"id":[{"id":"10.13039\/501100009327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2286\/23"],"award-info":[{"award-number":["2286\/23"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2026,10,14]]},"abstract":"<jats:p>\n                    A series of four titanium(IV) complexes based on asymmetric diaminobis(phenolato)\u2010bis(alkoxo) ligands with different substitutions and acetyl functional groups was synthesized and characterized. All complexes were analyzed by\n                    <jats:sup>1<\/jats:sup>\n                    H NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, and HRMS. Three complexes were analyzed by X\u2010ray crystallography; interestingly, whereas two complexes were similar to previously published structures showing\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    asymmetrical mononuclear octahedral coordination sphere, one structure of a bulky iodinated complex indicated formation of a unique pseudo\u2010\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    symmetrical hepta\u2010coordinated dimer, where computational studies indicated mostly subtle solvent and temperature effects. High hydrolytic stability was recorded for all derivatives, with\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>\u00bd<\/jats:sub>\n                    of more than 3 days for hydrolysis in 10% D\n                    <jats:sub>2<\/jats:sub>\n                    O organic solutions, with enhanced solubility in PBS\/DMSO (up to 0.25\u2009mg\/mL in &lt;0.5% DMSO aqueous solution). All complexes were highly cytotoxic toward human ovarian A2780 and colon HT\u201029 cancer cell lines (IC\n                    <jats:sub>50<\/jats:sub>\n                    values in the range of 0.5\u201310\u2009\u00b5M). Cellular uptake studies showed that the studied complexes possess marked membrane permeability, pointing to high potential as anticancer therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70519","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:59:22Z","timestamp":1791525562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ti(IV) Asymmetric Acetyl\u2010Substituted Phenolato Hexacoordinate Complexes as Anticancer Chemotherapy of Enhanced Bioavailability"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6129-6075","authenticated-orcid":false,"given":"Mohammad","family":"Taha","sequence":"first","affiliation":[{"name":"Institute of Chemistry The Hebrew University of Jerusalem, Edmond J. Safra Campus  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6227-829X","authenticated-orcid":false,"given":"Anwesh","family":"Pandey","sequence":"additional","affiliation":[{"name":"Institute of Drug research School of Pharmacy The Hebrew University of Jerusalem, Ein Kerem Campus  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avital","family":"Shurki","sequence":"additional","affiliation":[{"name":"Institute of Drug research School of Pharmacy The Hebrew University of Jerusalem, Ein Kerem Campus  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7452-3611","authenticated-orcid":false,"given":"Edit Y.","family":"Tshuva","sequence":"additional","affiliation":[{"name":"Institute of Chemistry The Hebrew University of Jerusalem, Edmond J. 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