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It is overexpressed in several human cancers. The proviral integration site of Moloney murine leukemia virus 1 is Pim\u20101. Previous studies have shown that the Pim\u20101 30\u2010UTR regulates the stability of Pim\u20101 mRNA. Threonine and serine are identified as the proto\u2010oncogene Pim\u20101 kinase. Pim\u20101 mediates numerous biological processes, including apoptosis, cell division, proliferation, and cancer. Pim\u20101\u2010mediated anticancer activity has been reported in several analogs of thiazole\/\n                    <jats:italic>bis<\/jats:italic>\n                    \u2010thiazole, tetrazine, thiophenes, quinoline, pyrazolopyrimidine, 3\u2010cyanopyridine, thiazolidine\u20102,4\u2010dione, thieno[2,3\u2010\n                    <jats:italic>b<\/jats:italic>\n                    ]pyridine, triazolo[4,3\u2010\n                    <jats:italic>b<\/jats:italic>\n                    ]pyridazine, pyrazolo[1,5\u2010\n                    <jats:italic>a<\/jats:italic>\n                    ]pyrimidines, and pyrazolo[3,4\u2010\n                    <jats:italic>b<\/jats:italic>\n                    ]pyridine derivatives. Additionally, flavonoids and amino alcohol compounds that constitute Pim\u20101\u2010mediated cancer therapy have also been identified thus far. Many compounds with Pim\u20101\u2010mediated cytotoxicity have been discovered up to this point, and scientists are currently concentrating on bringing novel compounds with anticancer potential to the market.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.70533","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:36:12Z","timestamp":1792031772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibitors of PIM\u20101 Signaling Pathways as Anticancer Agents: Pharmacological and Structural Viewpoints"],"prefix":"10.1002","volume":"21","author":[{"given":"Banty","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Uttar Pradesh University of Medical Sciences  Etawah U.P. 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