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MR imaging of both knees was performed at 2\u2009T before and up to 2\u2009h and 24\u2009h after injection (p.i.) of P866 (<jats:italic>n<\/jats:italic>\u2009=\u20093 dose finding study and <jats:italic>n<\/jats:italic>\u2009=\u20096, 0.02\u2009mmol Gd\/kg), the non\u2010FR targeted P866 analog P1001 (<jats:italic>n<\/jats:italic>\u2009=\u20093 at 24\u2009h after P866\u2010administration, 0.02\u2009mmol Gd\/kg) or Gd\u2010DOTA (<jats:italic>n<\/jats:italic>\u2009=\u20096, 0.1\u2009mmol Gd\/kg). Pulse sequences comprised <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010SPGR 80\u00b0\/50\u2009ms\/1.7\u2009ms (flip angle\/<jats:italic>TR<\/jats:italic>\/<jats:italic>TE<\/jats:italic>) and inversion recovery 10\u00b0\/3000\u2009ms\/1500\u2009ms\/50\u20133050, 10 000\u2009ms (flip angle\/<jats:italic>TR<\/jats:italic>\/<jats:italic>TE<\/jats:italic>\/<jats:italic>TI<\/jats:italic>) sequences. \u0394<jats:italic>SI<\/jats:italic>\u2010data and <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010relaxation times of arthritic knees and contralateral normal knees were determined. Folate receptor expression was confirmed with histopathology. All three contrast agents showed an initial perfusion effect with significantly higher \u0394<jats:italic>SI<\/jats:italic>\u2010data of arthritic knees compared with normal knees (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition, P866, but not P1001 or Gd\u2010DOTA, showed a prolonged enhancement of the synovitis. Compared with precontrast values, the <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010relaxation times of inflamed synovia were significantly decreased at 2\u2009h p.i. of P866 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), but not P1001 or Gd\u2010DOTA (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Histopathology confirmed the presence of folate receptors in the inflamed joints, but not normal joints. Thus, results suggest a specific accumulation of the folate receptor\u2010targeted Gd\u2010chelate P866 in this arthritis model. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cmmi.128","type":"journal-article","created":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T10:23:14Z","timestamp":1174990994000},"page":"72-81","source":"Crossref","is-referenced-by-count":20,"title":["MR imaging of antigen\u2010induced arthritis with a new, folate receptor\u2010targeted contrast agent"],"prefix":"10.1002","volume":"2","author":[{"given":"Olaf","family":"Saborowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard H.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Juergen","family":"Raatschen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Wendland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Henning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Baehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Corot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Hsiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike E.","family":"Daldrup\u2010Link","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441207"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar86"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199805)41:5<778::AID-ART4>3.0.CO;2-V"},{"key":"e_1_2_1_5_2","first-page":"1","article-title":"Summary health statistics for U. 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