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After intravenous injection, both tracers were rapidly cleared from all organs and were retained by the tumors. There was no significant difference in tumor uptake of the two tracers at all studied time points (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). To study the plausible mechanism of hypericin and mono\u2010iodohypericin uptake in tumor, their plasma binding profile was investigated. Both agents show high affinity for low\u2010density lipoproteins and to a lesser extent high\u2010density lipoproteins and other heavy proteins. Mono\u2010[<jats:sup>123<\/jats:sup>I]iodohypericin appears to be more promising as a tumor diagnostic agent, given its faster clearance from all organs. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cmmi.136","type":"journal-article","created":{"date-parts":[[2007,6,4]],"date-time":"2007-06-04T09:16:43Z","timestamp":1180948603000},"page":"113-119","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of tumor affinity of mono\u2010[<sup>123<\/sup>I]iodohypericin and mono\u2010[<sup>123<\/sup>I]iodoprotohypericin in a mouse model with a RIF\u20101 tumor"],"prefix":"10.1002","volume":"2","author":[{"given":"Humphrey","family":"Fonge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Van de Putte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Huyghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Bormans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicheng","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"de Witte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfons","family":"Verbruggen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00810594"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610150203"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/b315586b"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00057"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00381-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1324"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20285"},{"key":"e_1_2_1_9_2","first-page":"8241","article-title":"Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin","volume":"63","author":"Blank M","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_1_10_2","first-page":"655","article-title":"The impact of aggregation on the biodistribution of hypericin","volume":"28","author":"Van De Putte M","year":"2006","journal-title":"Int. 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