{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:44:30Z","timestamp":1791063870602,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T00:00:00Z","timestamp":1395187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contrast Media &amp; Molecular"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>To study the physicochemical properties of lanthanide complexes derived from a bifunctional chelating agent based on a PMN\u2010tetraacetic acid moiety {PMN\u2010tetraacetic acid (1): [2,6\u2010pyridinediyl<jats:italic>bis<\/jats:italic>(methylene nitrilo)\u2010tetraacetic acid]}, 4\u2010carboxylic acid substituted pyridine derivative (2) was synthesized. This ligand forms heptadentate (N<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>) Ln(III) complexes (Ln\u2009=\u2009Gd, Eu, Tb), with two water molecules completing the inner coordination sphere of the metal. The parameters that govern the relaxivity of the Gd(III) complex and the luminescence of Eu(III) and Tb(III) complexes were obtained by <jats:sup>17<\/jats:sup>O and <jats:sup>1<\/jats:sup>H NMR studies and time\u2010resolved fluorescence experiments, respectively. The gadolinium and terbium complexes show interesting properties either for MRI or FOR optical imaging; that is, for the Gd complex, a high proton relaxivity (<jats:italic>r<\/jats:italic><jats:sub>1<\/jats:sub>\u2009=\u20096.4\u2009s<jats:sup>\u22121<\/jats:sup>\u2009m<jats:sc>m<\/jats:sc><jats:sup>\u22121<\/jats:sup> at 20\u2009MHz) with short water residence time (<jats:italic>\u03c4<\/jats:italic><jats:sub>M<\/jats:sub>\u2009=\u200938.5\u2009ns); for the Tb complex, a luminescence lifetime of 1.22\u2009ms at room temperature and a luminescence quantum yield of 10%. The kinetic stability of these complexes toward blood protein, cation or bioactive oxyanion was also examined. The Gd(2)(H<jats:sub>2<\/jats:sub>O)<jats:sub>2<\/jats:sub> complex does not interact with human serum albumin, but undergoes a transmetalation reaction with Zn(II) in a phosphate buffer solution (pH\u20097.4), rather similar to that of Gd\u2013DTPA\u2013BMA(H<jats:sub>2<\/jats:sub>O). On the other hand, as observed for Eu and Tb complexes, these chelates do not form ternary complexes with bidentate anions such as <jats:sc>l<\/jats:sc>\u2010lactate, citrate or carbonate. Finally, a phosphatidylserine\u2010specific hexapeptide (TLVSSL) was grafted on Gd or Tb chelates, and the Gd\u2013peptide conjugate was used <jats:italic>in vitro<\/jats:italic> for targeting apoptotic cells. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cmmi.1576","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T10:07:04Z","timestamp":1395828424000},"page":"300-312","source":"Crossref","is-referenced-by-count":20,"title":["Bifunctional Gd(III) and Tb(III) chelates based on a pyridine\u2013<i>bis<\/i>(iminodiacetate) platform, suitable optical probes and contrast agents for magnetic resonance imaging"],"prefix":"10.1002","volume":"9","author":[{"given":"Sophie","family":"Laurent","sequence":"first","affiliation":[{"name":"NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry Universit\u00e9 de Mons  B\u20107000 Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luce","family":"Vander Elst","sequence":"additional","affiliation":[{"name":"NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry Universit\u00e9 de Mons  B\u20107000 Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Galaup","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Toulouse; UPS; Laboratoire de Synth\u00e8se et Physico\u2010Chimie de Mol\u00e9cules d'Int\u00e9r\u00eat Biologique, SPCMIB  118 route de Narbonne F\u201031062 Toulouse cedex 9 France"},{"name":"CNRS; Laboratoire de Synth\u00e8se et Physico\u2010Chimie de Mol\u00e9cules d'Int\u00e9r\u00eat Biologique, SPCMIB, UMR\u20105068  118 Route de Narbonne F\u201031062 Toulouse cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Leygue","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Toulouse; UPS; Laboratoire de Synth\u00e8se et Physico\u2010Chimie de Mol\u00e9cules d'Int\u00e9r\u00eat Biologique, SPCMIB  118 route de Narbonne F\u201031062 Toulouse cedex 9 France"},{"name":"CNRS; Laboratoire de Synth\u00e8se et Physico\u2010Chimie de Mol\u00e9cules d'Int\u00e9r\u00eat Biologique, SPCMIB, UMR\u20105068  118 Route de Narbonne F\u201031062 Toulouse cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Boutry","sequence":"additional","affiliation":[{"name":"NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry Universit\u00e9 de Mons  B\u20107000 Mons Belgium"},{"name":"Center for Microscopy and Molecular Imaging (CMMI), Acad\u00e9mie Wallonie\u2010Bruxelles  B 6041 Gosselies Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Picard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Toulouse; UPS; Laboratoire de Synth\u00e8se et Physico\u2010Chimie de Mol\u00e9cules d'Int\u00e9r\u00eat Biologique, SPCMIB  118 route de Narbonne F\u201031062 Toulouse cedex 9 France"},{"name":"CNRS; Laboratoire de Synth\u00e8se et Physico\u2010Chimie de Mol\u00e9cules d'Int\u00e9r\u00eat Biologique, SPCMIB, UMR\u20105068  118 Route de Narbonne F\u201031062 Toulouse cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert. 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