{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T20:51:47Z","timestamp":1761339107814},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T00:00:00Z","timestamp":1269475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contrast Media &amp; Molecular"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kupffer cell imaging is a powerful tool for the detection of liver cancer. This diagnostic procedure depends on the faculty of the reticuloendothelial system (RES) which takes up foreign bodies, including small particles. The current study aimed to develop a novel RES targeting liposomal contrast agent that functionalized with serine or mannose, the moiety specifically binding to a corresponding receptor on phagocytic cells. Liposomes loaded with non\u2010ionic X\u2010ray contrast media, Iohexol, were prepared by supercritical carbon dioxide reverse\u2010phase evaporation method and were intravenously injected to healthy rabbits in order to evaluate the liver parenchymal enhancement in X\u2010ray computed tomography (CT). From 10 to 40\u2009min after injection, the mean enhancement value of the liver parenchyma approached 45 and 34 Hounsfield units (HU) when serine\u2010modified iodinated liposomal contrast agent (ILCA) and mannose\u2010modified ILCA were applied, respectively. The tumor\u2010to\u2010liver contrast values were also evaluated after the administration of the prepared ILCA to rabbits with VX\u20102 carcinoma. For serine\u2010modified ILCA, tumor\u2010to\u2010liver contrast was 82 HU at 1\u2009min and &gt;24 HU at 10\u201340\u2009min; for mannose\u2010modified ILCA, the values were 58 HU at 0.5\u2009min and &gt;21 HU at 10\u201340\u2009min. These vales estimated from the region of intrest and the imaging figures of liver indicate the potential of ILCA for clinical use. 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