{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:16:44Z","timestamp":1754194604464},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contrast Media & Molecular"],"published-print":{"date-parts":[[2012,5]]},"abstract":"Ultrasmall superparamagnetic iron oxide (USPIO) particles are promising contrast media, especially for molecular and cellular imaging besides lymph node staging owing to their superior NMR efficacy, macrophage uptake and lymphotropic properties. The goal of the present prospective clinical work was to validate quantification of signal decrease on high\u2010resolution T<\/jats:italic>2<\/jats:sub>\u2010weighted MR sequences before and 24\u201336\u2009h after USPIO administration for accurate differentiation between benign and malignant normal\u2010sized pelvic lymph nodes. Fifty\u2010eight patients with bladder or prostate cancer were examined on a 3 T MR unit and their respective lymph node signal intensities (SI), signal\u2010to\u2010noise (SNR) and contrast\u2010to\u2010noise (CNR) were determined on pre\u2010 and post\u2010contrast 3D T<\/jats:italic>2<\/jats:sub>\u2010weighted turbo spin echo (TSE) images. Based on histology and\/or localization, USPIO\u2010uptake\u2010related SI\/SNR decrease of benign vs malignant and pelvic vs inguinal lymph nodes was compared. Out of 2182 resected lymph nodes 366 were selected for MRI post\u2010processing. Benign pelvic lymph nodes showed a significantly higher SI\/SNR decrease compared with malignant nodes (p<\/jats:italic>\u2009<\u20090.0001). Inguinal lymph nodes in comparison to pelvic lymph nodes presented a reduced SI\/SNR decrease (p<\/jats:italic>\u2009<\u20090.0001). CNR did not differ significantly between benign and malignant lymph nodes. The receiver operating curve analysis yielded an area under the curve of 0.96, and the point with optimal accuracy was found at a threshold value of 13.5% SNR decrease. Overlap of SI and SNR changes between benign and malignant lymph nodes were attributed to partial voluming, lipomatosis, histiocytosis or focal lymphoreticular hyperplasia. USPIO\u2010enhanced MRI improves the diagnostic ability of lymph node staging in normal\u2010sized lymph nodes, although some overlap of SI\/SNR\u2010changes remained. Quantification of USPIO\u2010dependent SNR decrease will enable the validation of this promising technique with the final goal of improving and individualizing patient care. Copyright \u00a9 2012 John Wiley & Sons, Ltd.<\/jats:p>","DOI":"10.1002\/cmmi.503","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T02:05:54Z","timestamp":1335492354000},"page":"346-355","source":"Crossref","is-referenced-by-count":21,"title":["Does quantification of USPIO uptake\u2010related signal loss allow differentiation of benign and malignant normal\u2010sized pelvic lymph nodes?"],"prefix":"10.1002","volume":"7","author":[{"given":"Johannes M.","family":"Froehlich","sequence":"first","affiliation":[{"name":"Department of Radiology, Neuroradiology and Nuclear Medicine University Hospital and Inselspital, University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Triantafyllou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Neuroradiology and Nuclear Medicine University Hospital and Inselspital, University of Bern Bern 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