{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:15:17Z","timestamp":1791155717947,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,28]],"date-time":"2001-12-28T00:00:00Z","timestamp":1009497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Hereditary pancreatic carcinoma shows extant phenotypic and genotypic heterogeneity as evidenced by its integral association with a variety of hereditary cancer syndromes inclusive of the familial atypical multiple mole melanoma (FAMMM) syndrome in concert with <jats:italic>CDKN2A<\/jats:italic> (<jats:italic>p16<\/jats:italic>) germline mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Creighton University's familial pancreatic carcinoma resource comprises 159 families of which 19 (12%) show the FAMMM cutaneous phenotypes. The authors describe eight families with the FAMMM\u2013pancreatic carcinoma (FAMMM\u2010PC) association in concert with a <jats:italic>CDKN2A<\/jats:italic> germline mutation. Each family was thoroughly educated about all facets of the study, including the molecular genetics, reduced penetrance of <jats:italic>CDKN2A<\/jats:italic> mutations, and their variable expressivity. Genetic counseling was provided to each patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Diversity in cancer presentation within and among the families was noteworthy, wherein melanoma predominated in certain of the families whereas pancreatic carcinoma predominated in others. Early\u2010onset pancreatic carcinoma (at ages 35, 45, 46, and 49 years) appeared in some of the families whereas markedly later\u2010onset pancreatic carcinoma occurred in others. There were four incidences of melanoma and pancreatic carcinoma as double primaries in the same individuals. One patient with melanoma and pancreatic carcinoma had a third primary of breast carcinoma. Another patient had sarcoma, esophageal carcinoma, and two melanoma primaries, whereas his daughter had sarcoma and was a carrier of a <jats:italic>CDKN2A<\/jats:italic> mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The authors suggest that these tumors may collectively, in concert with <jats:italic>CDKN2A<\/jats:italic> mutations, constitute a \u201cnew\u201d putative hereditary carcinoma syndrome referred to as FAMMM\u2010PC. More clinical and molecular genetic research on additional families with pancreatic carcinoma in concert with the FAMMM will be required. Cancer 2002;94:84\u201396. \u00a9 2002 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.10159","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T18:14:37Z","timestamp":1030299277000},"page":"84-96","source":"Crossref","is-referenced-by-count":177,"title":["Phenotypic variation in eight extended <i>CDKN2A<\/i> germline mutation familial atypical multiple mole melanoma\u2013pancreatic carcinoma\u2013prone families"],"prefix":"10.1002","volume":"94","author":[{"given":"Henry T.","family":"Lynch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall E.","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn 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