{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:08:10Z","timestamp":1791929290718,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,1,31]],"date-time":"2002-01-31T00:00:00Z","timestamp":1012435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Carcinomas of the skin are by far the most common human malignancies. Continuous exposure to ultraviolet (UV) light facilitates the development of precancerous lesions (actinic keratosis [AK]) that may progress to invasive squamous carcinomas. Apoptosis, triggered by the activation of CD95 (Fas), is one of the most important defense mechanisms against UV light\u2013induced carcinogenesis in experimental models, but the dynamics of CD95 expression in patients with sun\u2010induced lesions are largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors studied the expression of CD95 (Fas) in biopsy samples of normal skin (not exposed to sun) and compared it with chronically sun\u2010exposed skin (as evidenced by solar elastosis), AK, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), and keratoacanthomas (KA).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Normal skin keratinocytes expressed CD95 in cytoplasmic membranes and intercellular bridges in the basal layer. In chronically sun\u2010exposed keratinocytes (solar elastosis, no evidence of dysplasia), CD95 expression was up\u2010regulated and was observed throughout the entire thickness of the epidermis. However, in actinic keratosis there was a complete absence of Fas in approximately two\u2010thirds of the cases (8 of 12). In invasive SCC, CD95 was expressed focally and weakly only at the sites of contact with stromal lymphocytes. Keratoacanthomas consistently expressed CD95 at the interface with the inflammatory cells. No staining was observed in BCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>CD95 (Fas) up\u2010regulation in chronically sun\u2010exposed keratinocytes indicates an important role in the control of sun\u2010induced damage. Further sun exposure results, however, in significant down\u2010regulation of this defense mechanism, proportional to the degree of dysplasia. Cancer 2002;94:814\u20139. \u00a9 2002 American Cancer Society.<\/jats:p><jats:p>DOI 10.1002\/cncr.10277<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.10277","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T00:51:41Z","timestamp":1030236701000},"page":"814-819","source":"Crossref","is-referenced-by-count":41,"title":["Expression of CD95 (Fas) in sun\u2010exposed human skin and cutaneous carcinomas"],"prefix":"10.1002","volume":"94","author":[{"given":"Ewa","family":"Filipowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Adegboyega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. L.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Gatalica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1,31]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00283-X"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00371800"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(98)80222-7"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1999.tb01504.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.140.1.171"},{"key":"e_1_2_5_7_2","first-page":"731","volume-title":"Lever's histopathology of the skin","author":"Elder D","year":"1997"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000315)88:6<1378::AID-CNCR15>3.0.CO;2-I"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)61052-2"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90326-L"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90071-3"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81266-0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5429.898"},{"key":"e_1_2_5_14_2","first-page":"583","article-title":"Expression of p53 protein in actinic keratosis, adjacent, normal\u2010appearing, and non\u2010sun\u2010exposed human skin","volume":"6","author":"Einsphar J","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00090.x"},{"key":"e_1_2_5_16_2","first-page":"2081","article-title":"Induction of cancer, aktinic keratosis, and specific p53 mutation by UVB light in human skin maintained in severe combined immunodeficient mice","volume":"57","author":"Nomura T","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203662"},{"key":"e_1_2_5_18_2","first-page":"4638","article-title":"p53 promotes selection for Fas\u2010mediated apoptotic resistance","volume":"60","author":"Maecker HL","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64836-5"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01380.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1165"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971127)73:5<757::AID-IJC24>3.0.CO;2-1"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(98)00126-2"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00147.x"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.10277","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.10277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:10:01Z","timestamp":1760278201000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.10277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,31]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1002\/cncr.10277"],"URL":"https:\/\/doi.org\/10.1002\/cncr.10277","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,31]]}}}