{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:19:02Z","timestamp":1780924742587,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,3,11]],"date-time":"2002-03-11T00:00:00Z","timestamp":1015804800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>There is recent evidence that the incidence of indolent non\u2010Hodgkin lymphoma (NHL) appears to be increased in persons with the acquired immunodeficiency syndrome (AIDS). The current study was conducted to describe the clinical, immunologic, and pathologic characteristics of indolent B\u2010cell lymphoma in patients infected with the human immunodeficiency virus (HIV).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The current report was a retrospective study of 10 cases of indolent NHL identified from the AIDS\u2010Lymphoma Registry at the University of Southern California School of Medicine. These patients were compared with 336 consecutive patients with systemic intermediate\/high\u2010grade AIDS\u2010related NHL who were diagnosed and treated at a single institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The pathology of the indolent cases included follicular lymphoma (five patients), small lymphocytic lymphoma (two patients), and one case each of mucosa\u2010associated lymphoid tissue (MALT), monocytoid B\u2010cell, and marginal zone lymphoma. When comparing the indolent lymphomas with the intermediate\/high\u2010grade AIDS\u2010NHL cases, no differences were observed with regard to demographic characteristics or history of prior opportunistic infection. HIV patients with indolent lymphomas were found to have a significantly higher median CD4+ lymphocyte count compared with patients with intermediate\/high\u2010grade NHL (531 \/mm<jats:sup>3<\/jats:sup> vs. 90 \/mm<jats:sup>3<\/jats:sup>) (<jats:italic>P<\/jats:italic> &lt; 0.0001). Bone marrow involvement was significantly more common in indolent NHL cases (50%) versus intermediate\/high\u2010grade NHL cases (17%) (<jats:italic>P<\/jats:italic> = 0.02). The median survival for patients with indolent NHL was significantly longer compared with patients with intermediate\/high\u2010grade NHL (66.8 months vs. 7.1 months) (<jats:italic>P<\/jats:italic> = 0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Indolent lymphomas occurring in patients infected with HIV appear to differ from intermediate\/high\u2010grade lymphomas with regard to immune status and propensity for bone marrow involvement and prolonged survival. The median survival in the group of HIV\u2010seropositive patients with indolent NHL examined in the current study was found to be comparable to that reported in HIV\u2010negative individuals. Cancer 2002;94:1500\u20136. \u00a9 2002 American Cancer Society.<\/jats:p><jats:p>DOI 10.1002\/cncr.10368<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.10368","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:10:52Z","timestamp":1030302652000},"page":"1500-1506","source":"Crossref","is-referenced-by-count":29,"title":["Characteristics of indolent non\u2010hodgkin lymphoma in patients with type 1 human immunodeficiency virus infection"],"prefix":"10.1002","volume":"94","author":[{"given":"Alexandra M.","family":"Levine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Espina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Tulpule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Nathwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,3,11]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"277","article-title":"Diffuse undifferentiated non\u2010Hodgkin's lymphoma among homosexual males: United States","volume":"31","author":"Centers for Disease Control","year":"1982","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-1-7"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198408303110904"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-3-402"},{"issue":"4","key":"e_1_2_5_6_2","first-page":"390","article-title":"The epidemiology of acquired immunodeficiency syndrome malignancies","volume":"27","author":"Goedert JJ","year":"2000","journal-title":"Semin Oncol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971127)73:5<645::AID-IJC6>3.0.CO;2-X"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70380-4"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92513-2"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6770.203"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.22.1823"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7201.23"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.8.2730"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505043321802"},{"issue":"4","key":"e_1_2_5_15_2","first-page":"442","article-title":"Acquired immunodeficiency syndrome\u2010related lymphoma: clinical aspects","volume":"27","author":"Levine AM","year":"2000","journal-title":"Semin Oncol"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880601)61:11<2325::AID-CNCR2820611130>3.0.CO;2-0"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199612150-00014"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.292338.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.52.4.313"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199503000-00014"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(99)90052-2"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.2307\/2288652"},{"key":"e_1_2_5_23_2","first-page":"2505","volume-title":"SAS\/STAT users guide. 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