{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:52:20Z","timestamp":1782456740959,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,3,11]],"date-time":"2002-03-11T00:00:00Z","timestamp":1015804800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>A \u2212160 C \u2192 A polymorphism in the promoter region of <jats:italic>E\u2010cadherin<\/jats:italic> has been shown to decrease gene transcription. This allelic variation might be a potential genetic marker for identifying individuals at risk for cancer. There remains no report regarding the polymorphism of <jats:italic>E\u2010cadherin<\/jats:italic> in gastric carcinoma (GC).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A hospital\u2010based case\u2013control study, including 201 GC cases and 196 unaffected controls, was performed. DNA from peripheral blood samples was examined by polymerase chain reaction\u2013restriction fragment length polymorphism. Logistic regression analyses were used to compute odds ratio (OR) and 95% confidence interval (CI) after adjusted for <jats:italic>Helicobacter pylori<\/jats:italic> infection, smoking, and other relevant factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In 196 healthy Taiwanese, the distribution of genotype C\/C was 42.3%, C\/A was 48.0%, and A\/A was 9.7%. The frequency of variant A\/A genotype in GC case (4 of 201, 2%) was significantly lower than that of controls (19 of 196, 9.7%) (<jats:italic>P<\/jats:italic> &lt; 0.005), conferring a 5\u2010fold decrease in the risk of GC (OR, 0.20; 95% CI, 0.06\u20130.56) compared with the C\/C genotype. Stratification of the GC cases according to their location (cardia and noncardia), histology (intestinal and diffuse), tumor stage (early and advanced), and lymph node metastasis (positive and negative) failed to reveal any heterogeneity with respect to <jats:italic>E\u2010cadherin<\/jats:italic> genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The authors' data suggest that individuals with <jats:italic>E\u2010cadherin<\/jats:italic> \u2212160 A\/A genotype have a decreased risk of GC. Further work is mandatory to clarify the functional relevance of the A allele in vivo and to confirm the inverse association of the A\/A genotype with GC in large epidemiologic studies. Cancer 2002;94:1443\u20138. \u00a9 2002 American Cancer Society.<\/jats:p><jats:p>DOI 10.1002\/cncr.10371<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.10371","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:10:52Z","timestamp":1030302652000},"page":"1443-1448","source":"Crossref","is-referenced-by-count":57,"title":["Association of the \u2212160 C \u2192 a promoter polymorphism of <i>E\u2010cadherin<\/i> gene with gastric carcinoma risk"],"prefix":"10.1002","volume":"94","author":[{"given":"Ming\u2010Shiang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Pei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ting","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Tsan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Tung","family":"Shun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Po","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaw\u2010Town","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,3,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910540413"},{"key":"e_1_2_5_3_2","first-page":"6735","article-title":"Human gastric carcinogenesis","volume":"52","author":"Correa P","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01212724"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199412000-00001"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/20.12.2195"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507063330107"},{"key":"e_1_2_5_8_2","first-page":"281","article-title":"Epidemiology of gastric cancer","volume":"23","author":"Neugut AI","year":"1996","journal-title":"Semin Oncol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-12-199406150-00002"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.3.517"},{"key":"e_1_2_5_11_2","first-page":"675","article-title":"Cytochrome p4502E1 polymorphism in gastric cancer in Brazil: case\u2010control studies of Japanese Brazilians and Non\u2010Japanese Brazilians","volume":"9","author":"Nishimoto IN","year":"2000","journal-title":"Cancer Epidemiol Biomarker Prev"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/35006081"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8690208"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70356-8"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2006419"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/32918"},{"key":"e_1_2_5_17_2","first-page":"1690","article-title":"E\u2010cadherin expression in primary and metastatic gastric cancer: down\u2010regulation correlates with cellular dedifferentiation and glandular disintegration","volume":"53","author":"Mayer B","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_5_18_2","first-page":"873","article-title":"A single nucleotide polymorphism in the E\u2010cadherin gene promoter alters transcriptional activities","volume":"60","author":"Li LC","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_5_19_2","first-page":"1494","article-title":"Clinicopathological significance of altered loci of replication error and microsatellite instability\u2010associated mutations in gastric cancer","volume":"58","author":"Wu MS","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_5_20_2","first-page":"944","article-title":"An immunohistochemical study of E\u2010cadherin expression with correlations to clinicopathological features in gastric cancer","volume":"45","author":"Shun CT","year":"1996","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_21_2","volume-title":"Statistical methods for cancer epidemiology. 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