{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:34:06Z","timestamp":1790670846623,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,3,15]],"date-time":"2002-03-15T00:00:00Z","timestamp":1016150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2002,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Anaplastic large cell lymphoma (ALCL) is a relatively rare form of non\u2010Hodgkin lymphoma (NHL) in children constituting 10\u201315% of this entity. To the authors' knowledge, there are no population\u2010based pediatric studies in the literature, and incidence estimates have not been attempted.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A population\u2010based study of all children in British Columbia, Canada, younger than 15 years of age presenting between January 1988 and December 1999 with an immunohistologically confirmed diagnosis of CD30+ ALCL was completed. Demographic, ethnic, clinical, treatment, and outcome details were collected on all patients. Population figures were obtained from census data through the BC STATS.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Ten patients were identified and confirmed to have ALCL on the basis of morphology and immunohistochemical stains. This equates to an annual incidence of 1.2 per million children younger than 15 years of age. The mean age at diagnosis was 8.23 years with a range of 1.4\u201313.0 years. There was an overrepresentation of East and Southeast Asian patients (40%) in the ALCL group compared with other subtypes of NHL and the pediatric population of British Columbia. Twenty percent of the patients had evidence of central nervous system (CNS) disease at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The annual incidence of ALCL in children younger than 15 years of age in British Columbia is 1.2 per million. The overrepresentation of East and Southeast Asian ethnic origin remains unexplained. The rate of CNS involvement is much higher than that previously reported in large non\u2010population\u2010based series (0\u20133%). Although the low numbers do not allow firm conclusions, it would seem prudent to continue to investigate all newly diagnosed patients for CNS involvement in British Columbia. Cancer 2002;94:1830\u20135. \u00a9 2002 American Cancer Society.<\/jats:p><jats:p>DOI 10.1002\/cncr.10396<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.10396","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:42:44Z","timestamp":1030304564000},"page":"1830-1835","source":"Crossref","is-referenced-by-count":40,"title":["A population\u2010based study of pediatric anaplastic large cell lymphoma"],"prefix":"10.1002","volume":"94","author":[{"given":"Angela J.","family":"Alessandri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila L.","family":"Pritchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk R.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie G.","family":"Massing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,3,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V66.4.848.848"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/5.suppl_1.S31"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.50.2.128"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_7_6_2","first-page":"59","article-title":"Coexpression of epithelial membrane antigen (EMA), Ki\u20101 and interleukin\u20102 receptor by anaplastic large cell lymphomas: diagnostic value in so\u2010called malignant histiocytosis","volume":"130","author":"Delsol G","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb06270.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1182\/blood.V73.3.806.806","article-title":"A novel translocation t(2;5) (p25;q35) in childhood phagocytic large T\u2010cell lymphoma mimicking malignant histiocytosis","volume":"73","author":"Kaneko Y","year":"1989","journal-title":"Blood"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb02560.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8122112"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.9.4181"},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1128\/MCB.17.4.2312","article-title":"Role of nucleophosmin (NPM) portion of the non\u2010Hodgkin's lymphoma associated NPM\u2010anaplastic kinase fusion protein in oncogenesis","volume":"176","author":"Bischof D","year":"1997","journal-title":"Mol Cell Biol"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1182\/blood.V90.8.2901","article-title":"Retrovirus mediated transfer of the NPM\u2010ALK causes lymphoid malignancy in mice","volume":"90","author":"Kuefer MU","year":"1997","journal-title":"Blood"},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1182\/blood.V84.11.3648.bloodjournal84113648","article-title":"Diagnosis of t(2;5) (p25;q35)\u2010associated Ki\u20101 lymphoma with immunohistochemistry","volume":"84","author":"Shiota M","year":"1994","journal-title":"Blood"},{"key":"e_1_2_7_15_2","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1182\/blood.V89.4.1394","article-title":"Detection of ALK and NPM\u2010ALK protein in normal and neoplastic cells with the monoclonal antibody ALK 1","volume":"89","author":"Pulford K","year":"1997","journal-title":"Blood"},{"key":"e_1_2_7_16_2","volume-title":"Cancer incidence and survival among children and adolescents: United States SEER Program 1975\u20131995, National Cancer Institute, SEER Program","author":"Ries LAG","year":"1999"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00108-2"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950240503"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199505000-00011"},{"key":"e_1_2_7_20_2","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/0959-8049(94)00274-9","article-title":"Patterns and temporal trends in the incidence of malignant disease in children. 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