{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:06:13Z","timestamp":1792782373899,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2002,4,25]],"date-time":"2002-04-25T00:00:00Z","timestamp":1019692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Cancer Society","id":[{"id":"https:\/\/ror.org\/0527jb766","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Mrs. Berta Kamprads Foundation","id":[{"id":"https:\/\/ror.org\/04wv8j283","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Gunnar Arvid & Elisabeth Nilsson Foundation"},{"name":"Franke & Margareta Bergqvist Foundation"},{"name":"Lund University Hospital Foundations (Oncology)","id":[{"id":"https:\/\/ror.org\/012a77v79","id-type":"ROR","asserted-by":"crossref"}]},{"name":"King Gustav V's Jubilee Foundation","id":[{"id":"https:\/\/ror.org\/01a6tm809","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Endometrial carcinomas seem to carry a different prognosis depending on the presence or absence of concomitant complex atypical hyperplasia (hyperplasia). The molecular genetic profile of these two pathogenetic types, based on the genes reportedly mutated in these cancers, remains to be defined. Although microsatellite inability is reported in approximately 25% of endometrial carcinomas, its relation with the 2 pathogenetic types is not investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>To elucidate their underlying genetic changes, we analyzed 53 sporadic endometrial tumors, including 19 with and 34 without hyperplasia, for microsatellite instability (MSI), DNA ploidy (by flow cytometry), and for mutations in different genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Microsatellite instability was present in 21%, DNA nondiploidy in 15%, and mutations in the\n                      <jats:italic>PTEN, KRAS, CTNNB1\/\u03b2\u2010catenin, TP53,<\/jats:italic>\n                      and\n                      <jats:italic>CDKN2A<\/jats:italic>\n                      genes were detected in 32, 11, 13, 17, and 0% of the tumors, respectively. Microsatellite instability and mutations in these genes were present in tumors both with and without complex atypical hyperplasia. All cases with complex atypical hyperplasia were early stage (I\u2013II) endometrioid tumors and associated with long progression free disease (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0004). Furthermore, most tumors with hyperplasia had low World Health Organization or International Federation of Gynecology and Obstetrics grade, had less myometrial invasion, and showed expression of estrogen receptors. All MSI tumors were diploid and had a significantly higher rate of PTEN mutations, but similar rates of KRAS, \u03b2\u2010catenin, and TP53 mutations compared with microsatellite stable tumors. TP53 mutations more often were found in nondiploid tumors but never in tumors with PTEN, KRAS, or \u03b2\u2010catenin mutations, and all PTEN mutations occurred in diploid tumors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Thus,\n                      <jats:italic>PTEN, KRAS, \u03b2\u2010catenin,<\/jats:italic>\n                      and\n                      <jats:italic>TP53<\/jats:italic>\n                      mutations occurred in tumors both with and without hyperplasia, but\n                      <jats:italic>PTEN<\/jats:italic>\n                      and\n                      <jats:italic>TP53<\/jats:italic>\n                      mutations were more common in tumors without hyperplasia. However, none of these genes seems to clearly distinguish tumors with and without hyperplasia, suggesting that other factors may be involved. Conversely, alterations in the\n                      <jats:italic>PTEN<\/jats:italic>\n                      and\n                      <jats:italic>TP53<\/jats:italic>\n                      genes seem to define distinct subgroups of endometrial carcinoma, the former associated with diploidy and MSI, the latter with macroscopic chromosomal instability. Cancer 2002;94:2369\u201379. \u00a9 2002 American Cancer Society.\n                    <\/jats:p>\n                    <jats:p>DOI 10.1002\/cncr.10498<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.10498","type":"journal-article","created":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T03:57:47Z","timestamp":1098849467000},"page":"2369-2379","source":"Crossref","is-referenced-by-count":86,"title":["Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of 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