{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:26:27Z","timestamp":1762863987543,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2002,5,14]],"date-time":"2002-05-14T00:00:00Z","timestamp":1021334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2002,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The authors previously found the I1307K adenomatous polyposis coli (<jats:italic>APC<\/jats:italic>) gene variant in 5% of Ashkenazi control participants, in 15.4% of those who had familial colorectal neoplasia, but also in 1.6% of non\u2010Ashkenazi control participants. In this study, they evaluated its use in a screening program for familial colorectal neoplasia and examined for a founder effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Consecutive Ashkenazim with a personal and\/or family history of colorectal neoplasia had the DNA test. Markers flanking the <jats:italic>APC<\/jats:italic> gene were examined in Ashkenazi and non\u2010Ashkenazi I1307K carriers and noncarriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Among 718 persons, I1307K occurred in 6.2% of Ashkenazi participants, in 1.5% of non\u2010Ashkenazi control participants (<jats:italic>P<\/jats:italic> = 0.02), and in 10.7% of Ashkenazim with <jats:italic>familial<\/jats:italic> neoplasia (relative risk, 1.73 [not significant compared with controls]; 95% confidence interval, 0.7\u20133.2). Colorectal neoplasia was detected in carriers at a younger age (<jats:italic>P<\/jats:italic> &lt; 0.05) without excess risk for multiple colorectal neoplasia or noncolorectal neoplasia. I1307K attributable risk for colorectal neoplasia was 0.5\u20130.6%. Compared with noncarriers, both Ashkenazi and non\u2010Ashkenazi I1307K carriers had similar flanking polymorphic alleles (<jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>I1307K is a low\u2010penetrance genetic variant that indicates a 1.7 relative risk for neoplasia in carriers who have familial carcinoma, clinically equivalent to obtaining a family history of sporadic colorectal neoplasia and promoting early screening. I1307K is a founder genetic variant in Jews of different ethnic origin, mainly Ashkenazim, but it explains only partially their higher incidence of colorectal carcinoma. Cancer 2002;94:2561\u20138. \u00a9 2002 American Cancer Society.<\/jats:p><jats:p>DOI 10.1002\/cncr.10529<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.10529","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:28:18Z","timestamp":1030303698000},"page":"2561-2568","source":"Crossref","is-referenced-by-count":29,"title":["Clinical and screening implications of the I1307K adenomatous polyposis coli gene variant in Israeli Ashkenazi Jews with familial colorectal neoplasia"],"prefix":"10.1002","volume":"94","author":[{"given":"Paul","family":"Rozen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tova","family":"Naiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Strul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Taussky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataly","family":"Karminsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Shomrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziona","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Yaron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Orr\u2010Urtreger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-79"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70228-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/1722"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/302262"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000215)88:4<755::AID-CNCR4>3.0.CO;2-7"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21170"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870715)60:2<248::AID-CNCR2820600223>3.0.CO;2-G"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200325"},{"key":"e_1_2_6_10_2","first-page":"205","article-title":"Mutational 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