{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:30:36Z","timestamp":1775064636589,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,7,11]],"date-time":"2002-07-11T00:00:00Z","timestamp":1026345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2002,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The 1988 International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial carcinoma defined Stage IB as disease with invasion of less than one\u2010half of the myometrium, although most of the data on prognostic factors are based on invasion of the inner one\u2010third, middle one\u2010third, or outer one\u2010third of the myometrium. The objective of this study was to determine whether the depth of myometrial invasion is correlated with outcome in patients with Stage IB endometrial carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Between November, 1987 and June, 1998, 251 patients with Stage IB endometrioid adenocarcinoma of the uterus underwent simple hysterectomy followed by intravaginal brachytherapy. The depth of myometrial invasion was less than or equal to one\u2010third (Group I) in 191 of 251 patients (79%) and greater than one\u2010third to less than one\u2010half (Group II) in 52 of 251 patients (21%). Comprehensive surgical staging (CSS) was done in 12% of patients. The two groups were balanced with regard to age (&lt; 60 years vs. \u2265 60 years), FIGO grade, lower uterine segment involvement (LUSI), CSS, and the use of postoperative external\u2010beam radiation. The rate of capillary\u2010like space invasion (CLSI), however, was 9% in Group I compared with 25% in Group II (<jats:italic>P<\/jats:italic> = 0.002). The median follow\u2010up was 58 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The overall 5\u2010year actuarial local\u2010regional control (LRC), disease free (DFS) survival, and overall survival (OS) rates were 95%, 92%, and 92%, respectively. These end points, however, did not vary significantly between the two groups. The 5\u2010year LRC, DFS, and OS rates in Groups I and II were 96% versus 95%, respectively (<jats:italic>P<\/jats:italic> = 0.9); 92% versus 94%, respectively (<jats:italic>P<\/jats:italic> = 0.7); and 92% versus 90%, respectively (<jats:italic>P<\/jats:italic> = 0.5). On multivariate analysis, the influence on outcome of age, grade, amount of myometrial invasion, LUSI, and CLSI was evaluated. Only age \u2265 60 years and FIGO Grade 3 were correlated with poor DFS (<jats:italic>P<\/jats:italic> = 0.02 and <jats:italic>P<\/jats:italic> = 0.03, respectively) and OS (<jats:italic>P<\/jats:italic> = 0.001 and <jats:italic>P<\/jats:italic> = 0.01, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Based on this study, in patients with Stage IB endometrial carcinoma, the amount of myometrial invasion, defined as invasion less than or equal to one\u2010third of the myometrium versus invasion greater than one\u2010third and less than one\u2010half of the myometrium, did not appear to influence outcome. Age \u2265 60 years and FIGO Grade 3, however, emerged as independent prognostic factors for poor DFS and OS. Cancer 2002;95:316\u201321. \u00a9 2002 American Cancer Society.<\/jats:p><jats:p>DOI 10.1002\/cncr.10660<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.10660","type":"journal-article","created":{"date-parts":[[2002,10,10]],"date-time":"2002-10-10T15:45:16Z","timestamp":1034264716000},"page":"316-321","source":"Crossref","is-referenced-by-count":19,"title":["The significance of the amount of myometrial invasion in patients with Stage IB endometrial carcinoma"],"prefix":"10.1002","volume":"95","author":[{"given":"Kaled M.","family":"Alektiar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Mckee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ennapadam","family":"Venkatraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Zelefsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris R.","family":"Mychalczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brady","family":"Mckee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Hoskins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard R.","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,7,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"45","article-title":"Carcinoma of the corpus uteri","volume":"6","author":"Creasman WT","year":"2001","journal-title":"J Epidemiol Biostat."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(91)90086-K"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.1999.09901.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.1994.04020084.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(90)90018-G"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_6_8_2","first-page":"163","article-title":"Evaluation of survival data and two new ranks order statistics arising in its consideration","volume":"50","author":"Mantel N","year":"1966","journal-title":"Cancer Chemother Rep."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1972.tb00899.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.51.1.15"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910615)67:12<3093::AID-CNCR2820671226>3.0.CO;2-L"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5064"},{"key":"e_1_2_6_13_2","first-page":"419","article-title":"Postoperative external irradiation and prognostic parameters in Stage I endometrial carcinoma","volume":"56","author":"Aalders J","year":"1980","journal-title":"Obstet Gynecol."},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02139-5"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncr.10660","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.10660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:44:22Z","timestamp":1760265862000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.10660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,11]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,7,15]]}},"alternative-id":["10.1002\/cncr.10660"],"URL":"https:\/\/doi.org\/10.1002\/cncr.10660","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7,11]]}}}