{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T20:59:12Z","timestamp":1774731552643,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T00:00:00Z","timestamp":1047945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>It has been suggested that <jats:italic>BRCA<\/jats:italic>\u2010associated breast carcinoma may often lack a detectable preinvasive phase. To investigate this hypothesis, the authors compared the prevalence of histopathologic lesions in prophylactic mastectomy (PM) specimens from women with <jats:italic>BRCA<\/jats:italic> mutations and in mastectomy specimens obtained at autopsy from an age and race\u2010matched comparison group without a known cancer predisposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>All specimens from women with a deleterious <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> mutation who participated in an ongoing follow\u2010up study and underwent PM at Memorial Sloan\u2010Kettering Cancer Center between November 1, 1987 and May 31, 2001 were reviewed. For each case, breast tissue from two age and race\u2010matched women without a known cancer predisposition was also reviewed. The prevalence of benign, premalignant, and cancerous lesions was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Mastectomy specimens from 24 cases and 48 comparison subjects were reviewed. Ductal carcinoma in situ (DCIS), atypical ductal hyperplasia (ADH), and atypical lobular hyperplasia (ALH) were all more common in PM specimens from women with <jats:italic>BRCA<\/jats:italic> mutations than in those from the comparison group. The odds ratio for the detection of any high\u2010risk lesion (DCIS, lobular carcinoma in situ, ADH, or ALH) in specimens from <jats:italic>BRCA<\/jats:italic> mutation carriers was 12.7 (95% confidence interval, 3.1\u201352.4; <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Lesions associated with an increased risk of subsequent malignancy are more common in PM specimens from women with <jats:italic>BRCA<\/jats:italic> mutations than in breast tissue obtained at autopsy from unaffected women without a known predisposition. This finding suggests that hereditary breast carcinoma has a preinvasive phase that may be detectable with aggressive surveillance. Cancer 2003;97:1601\u20138. \u00a9 2003 American Cancer Society.<\/jats:p><jats:p>DOI 10.1002\/cncr.11225<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.11225","type":"journal-article","created":{"date-parts":[[2003,3,20]],"date-time":"2003-03-20T06:59:26Z","timestamp":1048143566000},"page":"1601-1608","source":"Crossref","is-referenced-by-count":79,"title":["Epithelial lesions in prophylactic mastectomy specimens from women with <i>BRCA<\/i> mutations"],"prefix":"10.1002","volume":"97","author":[{"given":"Noah D.","family":"Kauff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edi","family":"Brogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Scheuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy R.","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick I.","family":"Borgen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford A.","family":"Hudis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Offit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Robson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,3,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.4.924"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.5.1260"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)65027-1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)64441-8"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)10109-4"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871201)60:11<2751::AID-CNCR2820601127>3.0.CO;2-M"},{"key":"e_1_2_6_8_2","volume-title":"Diagnostic histopathology of the breast","author":"Page 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