{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:11:20Z","timestamp":1791915080957,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2003,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>A benign diagnosis in a core needle biopsy (CNBx) of the breast performed for a clinically and\/or radiologically suspicious abnormality is often due to a nonrepresentative sample. However, the discordance may not be recognized, resulting in a logistic delay in the diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty\u2010seven false\u2010negative CNBxs were identified in 952 consecutive CNBxs of the breast (653 benign, 266 malignant, and 33 atypical) performed during a 1\u2010year period. Biopsies were analyzed with respect to clinical and radiologic findings, biopsy type, type of malignancy, and interval between the original CNBx and final diagnosis. Four hundred thirty\u2010eight (67%) of the patients with a benign CNBx diagnosis either underwent excision or had a minimum of 1\u2010year follow\u2010up (mean, 35.6 months; median, 36 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The cancers missed on CNBx included 6 ductal carcinomas in situ, 17 invasive ductal carcinomas, 3 invasive lobular carcinomas, and 1 non\u2010Hodgkin lymphoma. The overall false\u2010negative rate was 9.1%. For palpable lesions, ultrasound\u2010guided CNBx had a lower rate of missed cancer (3.6%) compared with CNBx without image guidance (13.3%). The false\u2010negative rate for vacuum assisted CNBx biopsy was 7.6% (3.3% for the 11\u2010gauge needle, 22.2% for the 14\u2010gauge needle; 5.6% for nonpalpable mass lesions, 8.2% for microcalcifications). In all seven false\u2010negative CNBxs performed by radiologists, the discordance between the radiologic and pathologic findings was promptly recognized due to their standard follow\u2010up protocol. The discordance between the degree of clinical suspicion, radiologic impression, and the pathologic findings was not immediately recognized in 5 of 20 false\u2010negative CNBxs performed by surgeons (4 without radiologic guidance and 1 with ultrasound guidance), resulting in a delay in the diagnosis ranging from 112\u2013336 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>A false\u2010negative diagnosis of breast carcinoma was found to be more common in CNBx performed without image guidance but occurred to a lesser degree in image\u2010guided biopsies. A delay in diagnosis can be avoided by establishing a standard post\u2010CNBx follow\u2010up protocol. Cancer 2003;97:1824\u201331. \u00a9 2003 American Cancer Society.<\/jats:p><jats:p>DOI 10.1002\/cncr.11278<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.11278","type":"journal-article","created":{"date-parts":[[2003,4,2]],"date-time":"2003-04-02T12:37:22Z","timestamp":1049287042000},"page":"1824-1831","source":"Crossref","is-referenced-by-count":109,"title":["False\u2010negative core needle biopsies of the breast"],"prefix":"10.1002","volume":"97","author":[{"given":"Varsha I.","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Raju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjay","family":"Chitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernon","family":"Strand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197502)35:2<499::AID-CNCR2820350231>3.0.CO;2-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800710809"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880601)61:11<2273::AID-CNCR2820611122>3.0.CO;2-#"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198208000-00002"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800750906"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800791018"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800831029"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980215)82:4<679::AID-CNCR10>3.0.CO;2-V"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.180.2.1648757"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199806000-00017"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.183.3.1584909"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.188.2.8327696"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.4.8140997"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.2.7972743"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.187.2.8475299"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.17.1638"},{"key":"e_1_2_5_18_2","first-page":"743","article-title":"Interinstitutional comparison of performance in breast fine\u2010needle aspiration cytology: a Q\u2010Probe quality indicator study","volume":"115","author":"Zarbo RJ","year":"1991","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_5_19_2","first-page":"324","article-title":"Needle aspiration of the breast\u2014why bother?","volume":"20","author":"Kline TS","year":"1976","journal-title":"Acta Cytol."},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197910)44:4<1458::AID-CNCR2820440440>3.0.CO;2-T"},{"key":"e_1_2_5_21_2","first-page":"249","article-title":"Cytologic diagnosis of mammary tumors from aspiration biopsy smears: III. 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