{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:03:48Z","timestamp":1777392228311,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2003,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>To evaluate the role of primary reexcision (PRE) with scrotal resection in patients with paratesticular rhabdomyosarcoma enrolled in the German\u2010Italian Cooperative Studies. The authors compared patients who underwent this procedure, according to the protocol guidelines, with those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In 32 of 198 patients with localized disease, the primary surgery was performed through a noncorrect scrotal approach. Twenty\u2010four patients underwent PRE as recommended by the protocol guidelines (Group A) and 8 did not receive this treatment (Group B). The Group B patients were treated with the same chemotherapeutic regimens as the Group A patients and no radiotherapy was given to either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>After PRE, residual tumor was not detected in 21 of the 24 Group A patients. Twenty patients are alive in first complete remission 26\u2013250 months after diagnosis (median, 40 months), 2 are alive in second complete remission at 3 and 9 months from diagnosis of lymph node and lung recurrence, and 2 died of disease after lymph node and distant metastases at 16 and 13 months from diagnosis. Three\u2010fourths of these patients were older than 10 years old and the tumor was larger than 5 cm. The eight Group B patients are all alive in first complete remission 24\u2013250 months since diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The data on the eight patients who obtained local control without PRE or radiotherapy warrant further investigation. Because of the supposed high risk of contamination with subsequent microscopic residual tumor after a transcrotal approach, we emphasize the utility of PRE with hemiscrotectomy. Cancer 2003;97:1981\u20134. \u00a9 2003 American Cancer Society.<\/jats:p><jats:p>DOI 10.1002\/cncr.11284<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.11284","type":"journal-article","created":{"date-parts":[[2003,4,2]],"date-time":"2003-04-02T12:37:22Z","timestamp":1049287042000},"page":"1981-1984","source":"Crossref","is-referenced-by-count":32,"title":["Primary transcrotal excision for paratesticular rhabdomyosarcoma"],"prefix":"10.1002","volume":"97","author":[{"given":"Patrizia","family":"Dall'Igna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Bisogno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rn","family":"Treuner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Modesto","family":"Carli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Zanetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Guglielmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Cecchetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,4]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"319","volume-title":"Essentials of pediatric surgery","author":"Rowe MI","year":"1995"},{"key":"e_1_2_5_3_2","first-page":"17","article-title":"Rhabdomyosarcoma","volume":"6","author":"Andrassy RJ","year":"1997","journal-title":"Semin Pediatr Surg."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182966"},{"key":"e_1_2_5_5_2","first-page":"799","volume-title":"Principles and practice of pediatric oncology","author":"Wexler L","year":"1997"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(89)80290-8"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(200002)34:2<97::AID-MPO4>3.0.CO;2-8"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003830100580"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880115)61:2<209::AID-CNCR2820610202>3.0.CO;2-L"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.2.449"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921115)70:10<2557::AID-CNCR2820701027>3.0.CO;2-8"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63830-8"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1066091"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089168807400605"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871101)60:9<2337::AID-CNCR2820600937>3.0.CO;2-3"},{"issue":"2","key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0022-5347(17)38788-8","article-title":"Mortality in paratesticular rhabdomyosarcoma: a multivariate analysis","volume":"142","author":"La Qualglia MP","year":"1989","journal-title":"J Urol."},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/S0022-5347(17)39764-1","article-title":"Paratesticular rhabdomyosarcoma: results of therapy in 18 cases","volume":"144","author":"Blith B","year":"1990","journal-title":"J Urol."},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00024-0"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90400-X"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1986.tb05917.x"},{"key":"e_1_2_5_21_2","unstructured":"OberlinO RodaryC PraquinMT et al.Is it possible to cure RMS without local therapy?Results of the second study of the International Society of Pediatric Oncology (MMT84) [abstract]. 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