{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:26:43Z","timestamp":1791559603658,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2003,4,30]],"date-time":"2003-04-30T00:00:00Z","timestamp":1051660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2003,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>An optimal treatment modality for patients with primary gastrointestinal lymphoma has not yet been established. This study aimed to elucidate the clinicopathologic features of this disease and the influence of therapeutic modalities on the prognosis in Japanese patients<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The clinicopathologic features of 455 patients with primary gastrointestinal lymphoma were investigated retrospectively regarding treatment modalities and time trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      This study comprised 342 patients (75%) with gastric lymphoma, 96 patients (22%) with intestinal lymphoma, and 17 patients (4%) with both gastric and intestinal lymphoma. Two hundred thirty\u2010one (51%) patients were classified as having low\u2010grade B\u2010cell lymphoma including 200 marginal zone lymphoma of mucosa\u2010associated lymphoid tissue (MALT) type, 185 (41%) patients were classified as having high\u2010grade B\u2010cell lymphoma including 76 diffuse large cell lymphoma plus MALT lymphoma, and 39 (9%) patients were classified as having T\u2010cell lymphoma. The frequency of nonsurgical treatment, including\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      eradication, chemotherapy, and radiation, increased during the latest decade. Patients who received nonsurgical treatment showed a better overall survival than those treated by surgery, but event\u2010free survival did not differ between two groups. Cox multivariate analysis revealed that early stage, younger age, gastric localization, B\u2010cell phenotype, and absence of B symptoms were independent prognostic factors for better overall and event\u2010free survivals. Mucosa\u2010associated lymphoid tissue\u2010derived lymphoma was also an independent prognostic factor for event\u2010free survival, but not for overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Nonsurgical treatment may be an optimal therapeutic modality for patients with primary gastrointestinal lymphoma. Cancer 2003;97:2462\u201373. \u00a9 2003 American Cancer Society.<\/jats:p>\n                    <jats:p>DOI 10.1002\/cncr.11415<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.11415","type":"journal-article","created":{"date-parts":[[2003,4,30]],"date-time":"2003-04-30T22:01:10Z","timestamp":1051740070000},"page":"2462-2473","source":"Crossref","is-referenced-by-count":234,"title":["Primary gastrointestinal lymphoma in Japan"],"prefix":"10.1002","volume":"97","author":[{"given":"Shotaro","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masazumi","family":"Tsuneyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,4,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196908000-00011"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO;2-#"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(85)90042-2"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1989.351"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196908000-00010"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<693::AID-CNCR2820420241>3.0.CO;2-J"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198005000-00011"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800701)46:1<215::AID-CNCR2820460136>3.0.CO;2-6"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820315)49:6<1258::AID-CNCR2820490630>3.0.CO;2-4"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850301)55:5<1060::AID-CNCR2820550523>3.0.CO;2-8"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000226009"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880115)61:2<309::AID-CNCR2820610221>3.0.CO;2-J"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890915)64:6<1208::AID-CNCR2820640608>3.0.CO;2-Z"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1989.262"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90509-V"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(91)90902-P"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91723-H"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91061-L"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.141"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058388"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1993.tb00157.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90742-0"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.8.1673"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900130305"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.18.3861"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_5_29_2","volume-title":"World Health Organization classification of tumours. 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