{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T10:35:40Z","timestamp":1781606140116,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,6,16]],"date-time":"2003-06-16T00:00:00Z","timestamp":1055721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2003,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The purpose of the current study was to determine the frequency of \u2018probably benign\u2019 interpretations at breast magnetic resonance (MR) imaging screening of high\u2010risk women and the frequency of subsequent malignancy in these women.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors performed a retrospective review of the records of 367 asymptomatic women with normal mammograms who had a high risk of developing breast cancer and whose first breast MR imaging screening examinations occurred during a 2\u2010year period. The number of \u201cprobably benign\u201d interpretations was determined, and follow\u2010up data were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A \u201cprobably benign\u201d interpretation was given to 89 (24%) of 367 women. Follow\u2010up MR imaging was performed for 70 (79%) of 89 women, with a median follow\u2010up time of 11 months (range, 1\u201324 months). Twenty women subsequently underwent biopsy at a median of 9 months (range, 1\u201318 months) after MR imaging, due to progression on follow\u2010up MR imaging (<jats:italic>n<\/jats:italic> = 14) or for other reasons (<jats:italic>n<\/jats:italic> = 6). Malignancies were found in 9 women, constituting 45% of the 20 women who underwent biopsy and 10% of the 89 women with probably benign lesions. In 6 of the 9 women who developed malignant disease (7% of the 89 women in the study), the malignancy was detected by follow\u2010up MR imaging of an area that previously was interpreted as probably benign. Tumor histology was ductal carcinoma in situ (DCIS) in five patients and infiltrating ductal carcinoma in four.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>A \u201cprobably benign\u201d interpretation was given to 24% of high\u2010risk women at their first breast MR imaging screening examination. In 7\u201310% of women with \u201cprobably benign\u201d interpretations, malignant disease subsequently developed in an area initially judged to be probably benign; of these malignancies, more than half were DCIS, and more than half were detected by MR imaging only. Cancer 2003;98:377\u201388. \u00a9 2003 American Cancer Society.<\/jats:p><jats:p>DOI 10.1002\/cncr.11491<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncr.11491","type":"journal-article","created":{"date-parts":[[2003,7,14]],"date-time":"2003-07-14T13:08:11Z","timestamp":1058188091000},"page":"377-388","source":"Crossref","is-referenced-by-count":97,"title":["Probably benign lesions at breast magnetic resonance imaging"],"prefix":"10.1002","volume":"98","author":[{"given":"Laura","family":"Liberman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine L.","family":"Benton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea F.","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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